A Kesler1,2, N Stolovic1, Y Bluednikov3, T Shohat3,4. 1. Neuro-ophthalmology Unit, Department of Ophthalmology, Tel-Aviv Sourasky Medical Center, Tel Aviv, Israel. 2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 3. Israel Center for Disease Control, Ministry of Health, Tel Hashomer, Israel. 4. Department of Epidemiology and Preventive Medicine, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Abstract
BACKGROUND AND PURPOSE: Idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri, is a disorder related to increased intracranial pressure without clinical, laboratory or radiological evidence of an intracranial space occupying lesion or cerebral sinus vein thrombosis, predominantly affecting obese women of childbearing age. Our aim was to determine the incidence and clinical features of IIH in Israel. METHODS: In a cross-sectional study, all medical records of patients discharged from the hospital with a primary diagnosis of IIH during 2005-2007 were reviewed. RESULTS: Four hundred and twenty-eight patients with a new onset of IIH were diagnosed. The average annual incidence rate was 2.02 per 100,000 with an incidence of 3.17 per 100,000 for women and 0.85 per 100,000 for men. The incidence rate in females of childbearing age (18-45) was 5.49 per 100,000. The female to male ratio for >17 years old was 6.1:1 (252 females and 41 males) and 2.1:1 (60 females and 28 males) for ages 11-17. Obesity was documented in 83.4% of patients. Body mass index (BMI) data were available for 159 (37.1%) patients; of these, 59.1% had a BMI ≥ 30. CONCLUSION: The incidence of IIH in Israel has increased during the last decade. This finding could be related to the increasing rates of obesity. The association of IIH and obesity should be further explored especially with regard to the effect of weight reduction for primary prevention.
BACKGROUND AND PURPOSE:Idiopathic intracranial hypertension (IIH), also known as pseudotumor cerebri, is a disorder related to increased intracranial pressure without clinical, laboratory or radiological evidence of an intracranial space occupying lesion or cerebral sinus vein thrombosis, predominantly affecting obesewomen of childbearing age. Our aim was to determine the incidence and clinical features of IIH in Israel. METHODS: In a cross-sectional study, all medical records of patients discharged from the hospital with a primary diagnosis of IIH during 2005-2007 were reviewed. RESULTS: Four hundred and twenty-eight patients with a new onset of IIH were diagnosed. The average annual incidence rate was 2.02 per 100,000 with an incidence of 3.17 per 100,000 for women and 0.85 per 100,000 for men. The incidence rate in females of childbearing age (18-45) was 5.49 per 100,000. The female to male ratio for >17 years old was 6.1:1 (252 females and 41 males) and 2.1:1 (60 females and 28 males) for ages 11-17. Obesity was documented in 83.4% of patients. Body mass index (BMI) data were available for 159 (37.1%) patients; of these, 59.1% had a BMI ≥ 30. CONCLUSION: The incidence of IIH in Israel has increased during the last decade. This finding could be related to the increasing rates of obesity. The association of IIH and obesity should be further explored especially with regard to the effect of weight reduction for primary prevention.
Authors: Keira A Markey; Maria Uldall; Hannah Botfield; Liam D Cato; Mohammed A L Miah; Ghaniah Hassan-Smith; Rigmor H Jensen; Ana M Gonzalez; Alexandra J Sinclair Journal: J Pain Res Date: 2016-04-19 Impact factor: 3.133
Authors: Keira Annie Markey; Ryan Ottridge; James L Mitchell; Caroline Rick; Rebecca Woolley; Natalie Ives; Peter Nightingale; Alexandra J Sinclair Journal: JMIR Res Protoc Date: 2017-09-18