| Literature DB >> 24694525 |
Masaaki Niino1, Toshiyuki Fukazawa2, Yusei Miyazaki3, Eri Takahashi4, Naoya Minami5, Itaru Amino5, Naoto Fujiki5, Shizuki Doi5, Seiji Kikuchi5.
Abstract
We investigated whether calcitriol (1,25-dihydroxyvitamin D) differentially modulates cytokine production by peripheral blood mononuclear cells from multiple sclerosis (MS) patients compared with that from healthy controls. In response to phytohemagglutinin (PHA) or lipopolysaccharide (LPS), cytokine level in a calcitriol-added sample was normalized to that in a calcitriol-absent sample, and this relative unit was compared. The relative unit of IL-12/23(p40) in LPS-stimulation was higher in MS patients. Moreover, the relative unit of IL-10 in PHA-stimulation was lower in MS patients, and negatively correlated with the Expanded Disability Status Scale. The anti-inflammatory response to vitamin D may be reduced in MS.Entities:
Keywords: Cytokine; Disability; IL-10; Multiple sclerosis; Vitamin D
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Year: 2014 PMID： 24694525 DOI： 10.1016/j.jneuroim.2014.03.011
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478