Literature DB >> 24692046

Implementation of a Gaussian beam laser and aspheric optics for high spatial resolution MALDI imaging MS.

Andre Zavalin1, Junhai Yang, Andreas Haase, Armin Holle, Richard Caprioli.   

Abstract

We have investigated the use of a Gaussian beam laser for MALDI Imaging Mass Spectrometry to provide a precisely defined laser spot of 5 μm diameter on target using a commercial MALDI TOF instrument originally designed to produce a 20 μm diameter laser beam spot at its smallest setting. A Gaussian beam laser was installed in the instrument in combination with an aspheric focusing lens. This ion source produced sharp ion images at 5 μm spatial resolution with signals of high intensity as shown for images from thin tissue sections of mouse brain.

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Year:  2014        PMID： 24692046      PMCID： PMC4035219          DOI： 10.1007/s13361-014-0872-5

Source DB:  PubMed          Journal:  J Am Soc Mass Spectrom        ISSN： 1044-0305            Impact factor:   3.109


  6 in total

1.  Laser microprobe mass analysis of organic materials.

Authors:  F Hillenkamp; E Unsöld; R Kaufmann; R Nitsche
Journal:  Nature       Date:  1975-07-10       Impact factor: 49.962

2.  Matrix sublimation/recrystallization for imaging proteins by mass spectrometry at high spatial resolution.

Authors:  Junhai Yang; Richard M Caprioli
Journal:  Anal Chem       Date:  2011-06-28       Impact factor: 6.986

3.  Optimizing UV laser focus profiles for improved MALDI performance.

Authors:  Armin Holle; Andreas Haase; Markus Kayser; Jens Höhndorf
Journal:  J Mass Spectrom       Date:  2006-06       Impact factor: 1.982

4.  The effect of laser profile, fluence, and spot size on sensitivity in orthogonal-injection matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Authors:  Hui Qiao; Victor Spicer; Werner Ens
Journal:  Rapid Commun Mass Spectrom       Date:  2008-09       Impact factor: 2.419

5.  Molecular imaging of biological samples: localization of peptides and proteins using MALDI-TOF MS.

Authors:  R M Caprioli; T B Farmer; J Gile
Journal:  Anal Chem       Date:  1997-12-01       Impact factor: 6.986

6.  Laser beam filtration for high spatial resolution MALDI imaging mass spectrometry.

Authors:  Andre Zavalin; Junhai Yang; Richard Caprioli
Journal:  J Am Soc Mass Spectrom       Date:  2013-05-10       Impact factor: 3.109
  6 in total
  10 in total

1.  Single-Cell Metabolomics by Mass Spectrometry Imaging.

Authors:  Maria Emilia Dueñas; Young Jin Lee
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

2.  High spatial resolution imaging mass spectrometry of human optic nerve lipids and proteins.

Authors:  David M G Anderson; Jeffrey M Spraggins; Kristie L Rose; Kevin L Schey
Journal:  J Am Soc Mass Spectrom       Date:  2015-04-17       Impact factor: 3.109

Review 3.  Mass Spectrometry Imaging for Spatial Chemical Profiling of Vegetative Parts of Plants.

Authors:  Akhila Ajith; Phillip J Milnes; Giles N Johnson; Nicholas P Lockyer
Journal:  Plants (Basel)       Date:  2022-05-02

4.  Discovering New Lipidomic Features Using Cell Type Specific Fluorophore Expression to Provide Spatial and Biological Specificity in a Multimodal Workflow with MALDI Imaging Mass Spectrometry.

Authors:  Marissa A Jones; Sung Hoon Cho; Nathan Heath Patterson; Raf Van de Plas; Jeffrey M Spraggins; Mark R Boothby; Richard M Caprioli
Journal:  Anal Chem       Date:  2020-05-06       Impact factor: 6.986

5.  Optically Guided Single Cell Mass Spectrometry of Rat Dorsal Root Ganglia to Profile Lipids, Peptides and Proteins.

Authors:  Thanh D Do; Joseph F Ellis; Elizabeth K Neumann; Troy J Comi; Emily G Tillmaand; Ashley E Lenhart; Stanislav S Rubakhin; Jonathan V Sweedler
Journal:  Chemphyschem       Date:  2018-04-17       Impact factor: 3.102

6.  Tip-enhanced laser ablation sample transfer for biomolecule mass spectrometry.

Authors:  Suman Ghorai; Chinthaka A Seneviratne; Kermit K Murray
Journal:  J Am Soc Mass Spectrom       Date:  2014-10-07       Impact factor: 3.109

Review 7.  Proteomic characterization of the human lens and Cataractogenesis.

Authors:  Lee S Cantrell; Kevin L Schey
Journal:  Expert Rev Proteomics       Date:  2021-04-14       Impact factor: 4.250

8.  Bis(monoacylglycero)phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas.

Authors:  David M G Anderson; Zsolt Ablonczy; Yiannis Koutalos; Anne M Hanneken; Jeffrey M Spraggins; M Wade Calcutt; Rosalie K Crouch; Richard M Caprioli; Kevin L Schey
Journal:  Sci Rep       Date:  2017-12-11       Impact factor: 4.379

9.  Comparison of Vacuum MALDI and AP-MALDI Platforms for the Mass Spectrometry Imaging of Metabolites Involved in Salt Stress in Medicago truncatula.

Authors:  Caitlin Keller; Junko Maeda; Dhileepkumar Jayaraman; Sanhita Chakraborty; Michael R Sussman; Jeanne M Harris; Jean-Michel Ané; Lingjun Li
Journal:  Front Plant Sci       Date:  2018-08-28       Impact factor: 5.753

Review 10.  Mapping the Chemistry of Hair Strands by Mass Spectrometry Imaging-A Review.

Authors:  Mai H Philipsen; Emma R Haxen; Auraya Manaprasertsak; Per Malmberg; Emma U Hammarlund
Journal:  Molecules       Date:  2021-12-11       Impact factor: 4.411
  10 in total

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