Literature DB >> 24691058

Chromones as a privileged scaffold in drug discovery: a review.

Rangappa S Keri1, Srinivasa Budagumpi2, Ranjith Krishna Pai2, R Geetha Balakrishna2.   

Abstract

The chromone and its derivatives are the most important heterocyclic compounds, which is a common and integral feature of a variety of natural products and medicinal agents. These heterocycles show a variety of pharmacological properties, and change of their structure offers a high degree of diversity that has proven useful for the search of new therapeutic agents. A large volume of research has been carried out on chromone and their derivatives, which has proved the pharmacological importance of this heterocyclic nucleus. The present review focuses on the pharmacological profile of chromone derivatives in the current literature with an update of recent research findings on this nucleus and the perspectives that they hold for future research.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Chromone; Heterocycles; Pharmacological activities; Synthesis

Mesh:

Substances:

Year:  2014        PMID: 24691058     DOI: 10.1016/j.ejmech.2014.03.047

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN: 0223-5234            Impact factor:   6.514


  35 in total

1.  A theoretical evaluation on free radical scavenging activity of 3-styrylchromone derivatives: the DFT study.

Authors:  Emre Çakmak; Dilara Özbakır Işın
Journal:  J Mol Model       Date:  2020-04-11       Impact factor: 1.810

Review 2.  Synthesis of Biologically Active Molecules through Multicomponent Reactions.

Authors:  Daniel Insuasty; Juan Castillo; Diana Becerra; Hugo Rojas; Rodrigo Abonia
Journal:  Molecules       Date:  2020-01-24       Impact factor: 4.411

Review 3.  Styrylchromones: Biological Activities and Structure-Activity Relationship.

Authors:  Mariana Lucas; Marisa Freitas; Artur M S Silva; Eduarda Fernandes; Daniela Ribeiro
Journal:  Oxid Med Cell Longev       Date:  2021-12-22       Impact factor: 6.543

4.  Investigation of Direct and Retro Chromone-2-Carboxamides Based Analogs of Pseudomonas aeruginosa Quorum Sensing Signal as New Anti-Biofilm Agents.

Authors:  Jeanne Trognon; Gonzalo Vera; Maya Rima; Jean-Luc Stigliani; Laurent Amielet; Salomé El Hage; Barbora Lajoie; Christine Roques; Fatima El Garah
Journal:  Pharmaceuticals (Basel)       Date:  2022-03-29

Review 5.  Multi-Target Drug Candidates for Multifactorial Alzheimer's Disease: AChE and NMDAR as Molecular Targets.

Authors:  Md Sahab Uddin; Abdullah Al Mamun; Md Tanvir Kabir; Ghulam Md Ashraf; May N Bin-Jumah; Mohamed M Abdel-Daim
Journal:  Mol Neurobiol       Date:  2020-09-15       Impact factor: 5.590

6.  A novel synthetic microtubule inhibitor exerts antiproliferative effects in multidrug resistant cancer cells and cancer stem cells.

Authors:  Mina Park; Jee Won Hwang; Yena Cho; Saegun Kim; Sang Hoon Han; Jinsuh Yu; Sojung Ha; Woo-Young Kim; Su-Nam Kim; In Su Kim; Yong Kee Kim
Journal:  Sci Rep       Date:  2021-05-24       Impact factor: 4.379

7.  Rapid synthetic approaches to libraries of diversified 1,2-dihydrochromeno[2,3-c]pyrrole-3,9-diones and 3-(2-hydroxyphenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(1H)-ones.

Authors:  Roman N Vydzhak; Svitlana Ya Panchishin; Maryna V Kachaeva; Stepan G Pilyo; Viktoriia S Moskvina; Olga V Shablykina; Andriy V Kozytskiy; Volodymyr S Brovarets
Journal:  Mol Divers       Date:  2021-06-04       Impact factor: 3.364

8.  Reverse orientation in the ultrasound-assisted [3 + 2]-cycloaddition reaction of nitrile imines with 3-formylchromone-Meldrum's acid adducts.

Authors:  Issa Yavari; Younes Fadakar
Journal:  Mol Divers       Date:  2021-06-15       Impact factor: 2.943

9.  Bioactive chromone constituents from Vitex negundo alleviate pain and inflammation.

Authors:  Ajmal Khan; Sadia Naz; Umar Farooq; Muhammad Shahid; Irfan Ullah; Iftikhar Ali; Abdur Rauf; Yahia Nasser Mabkhot
Journal:  J Pain Res       Date:  2017-12-28       Impact factor: 3.133

10.  Identification of potent chromone embedded [1,2,3]-triazoles as novel anti-tubercular agents.

Authors:  Viswanadh Nalla; Aslam Shaikh; Sanket Bapat; Renu Vyas; M Karthikeyan; P Yogeeswari; D Sriram; M Muthukrishnan
Journal:  R Soc Open Sci       Date:  2018-04-04       Impact factor: 2.963

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