2-D PSTD Simulation of the time-reversed ultrasound-encoded deep-tissue imaging technique.

We present a robust simulation technique to model the time-reversed ultrasonically encoded (TRUE) technique for deep-tissue imaging. The pseudospectral time-domain (PSTD) algorithm is employed to rigorously model the electromagnetic wave interaction of light propagating through a macroscopic scattering medium. Based upon numerical solutions of Maxwell's equations, the amplitude and phase are accurately accounted for to analyze factors that affect the TRUE propagation of light through scattering media. More generally, we demonstrate the feasibility of modeling light propagation through a virtual tissue model of macroscopic dimensions with numerical solutions of Maxwell's equations.