Chuck W Lynde1, Anneke Andriessen2, Benjamin Barankin3, Gillian De Gannes4, Wayne Gulliver5, Richard Haber6, Catherine McCuaig7, Poonam Rajan8, Sandra P Skotnicki8, Richard Thomas9, Jack Toole10, Ron Vender11. 1. University of Toronto, Toronto, Ontario, Canada. 2. Andriessen Consultants, Maiden & UMC St Radboud, Nijmegen, The Netherlands. 3. Toronto Dermatology Center, Toronto, Ontario. 4. Vancouver, British Columbia, Canada. 5. St. John's, The Netherlands. 6. University of Calgary, Calgary, Alberta, Canada. 7. Montreal, Quebec, Canada. 8. Toronto, Ontario, Canada. 9. The University of British Columbia, Vancouver, British Columbia, Canada. 10. University of Manitoba, Winnipeg, Manitoba, Canada. 11. McMaster University, Hamilton, Ontario, Canada.
Abstract
INTRODUCTION: Ceramide-containing moisturizers may offer benefits as an adjunct to acne treatment. METHODS: An expert panel of 11 Canadian dermatologists, including an international clinical scientist, used the following modified Delphi process: 1) A systematic literature review for acne treatment, dry skin, irritation, depletion of ceramides in acne, and benefits of moisturizers and ceramide-containing moisturizers was conducted; 2) panel members gave their opinion on the resulting statements, taking into account their treatment practices; 3) a panel meeting was held during the 2011 Canadian Dermatology Update to determine final statements; 4) the panel reviewed the final document. RESULTS: The panel reached the following consensus (11/11): 1) A very important reason for nonadherence to acne treatment is dry skin and irritation; 2) skin barrier dysfunction may contribute to acne; 3) dry skin and irritation commonly results from topical acne treatment; 4) dry skin and irritation commonly results from systemic retinoid therapy; 5) moisturizers can improve dryness and irritation resulting from acne treatment; 6) ceramide-containing moisturizers may enhance adherence and complement existing acne therapies; 7) adjunctive therapy with moisturizers should be considered in acne-treated patients. CONCLUSION: The panel proposes that adjunctive therapy with moisturizers, particularly ceramide-containing moisturizers, should be considered in acne-treated patients.
INTRODUCTION:Ceramide-containing moisturizers may offer benefits as an adjunct to acne treatment. METHODS: An expert panel of 11 Canadian dermatologists, including an international clinical scientist, used the following modified Delphi process: 1) A systematic literature review for acne treatment, dry skin, irritation, depletion of ceramides in acne, and benefits of moisturizers and ceramide-containing moisturizers was conducted; 2) panel members gave their opinion on the resulting statements, taking into account their treatment practices; 3) a panel meeting was held during the 2011 Canadian Dermatology Update to determine final statements; 4) the panel reviewed the final document. RESULTS: The panel reached the following consensus (11/11): 1) A very important reason for nonadherence to acne treatment is dry skin and irritation; 2) skin barrier dysfunction may contribute to acne; 3) dry skin and irritation commonly results from topical acne treatment; 4) dry skin and irritation commonly results from systemic retinoid therapy; 5) moisturizers can improve dryness and irritation resulting from acne treatment; 6) ceramide-containing moisturizers may enhance adherence and complement existing acne therapies; 7) adjunctive therapy with moisturizers should be considered in acne-treated patients. CONCLUSION: The panel proposes that adjunctive therapy with moisturizers, particularly ceramide-containing moisturizers, should be considered in acne-treated patients.