| Literature DB >> 24681112 |
Liang Ge1, Sulochanadevi Baskaran2, Randy Schekman1, James H Hurley3.
Abstract
The biogenesis of autophagosomes entails the nucleation and growth of a double-membrane sheet, the phagophore, which engulfs cytosol for delivery to the lysosome. Genetic studies have identified a class of Atg proteins that are essential for the process, yet the molecular mechanism of autophagosome biogenesis has been elusive. Proteomic, structural, super-resolution imaging, and biochemical reconstitution experiments have begun to fill in some of the gaps. This review describes progress and prospects for obtaining a four-dimensional network model of the nucleation and growth of the phagophore.Mesh：
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Year: 2014 PMID： 24681112 DOI： 10.1016/j.ceb.2014.02.005
Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382