Literature DB >> 24680878

DNA-PK: a dynamic enzyme in a versatile DSB repair pathway.

Anthony J Davis1, Benjamin P C Chen1, David J Chen2.   

Abstract

DNA double stranded breaks (DSBs) are the most cytoxic DNA lesion as the inability to properly repair them can lead to genomic instability and tumorigenesis. The prominent DSB repair pathway in humans is non-homologous end-joining (NHEJ). In the simplest sense, NHEJ mediates the direct re-ligation of the broken DNA molecule. However, NHEJ is a complex and versatile process that can repair DSBs with a variety of damages and ends via the utilization of a significant number of proteins. In this review we will describe the important factors and mechanisms modulating NHEJ with emphasis given to the versatility of this repair process and the DNA-PK complex.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  DNA double strand breaks; DNA ligase IV; DNA-PKcs; Ku70/80; Non-homologous end-joining; XLF; XRCC4

Mesh：

Substances：

Year:  2014        PMID： 24680878      PMCID： PMC4032623          DOI： 10.1016/j.dnarep.2014.02.020

Source DB:  PubMed          Journal:  DNA Repair (Amst)        ISSN： 1568-7856


  148 in total

1.  Heat shock protein 90α (Hsp90α) is phosphorylated in response to DNA damage and accumulates in repair foci.

Authors:  Maria Quanz; Aurélie Herbette; Mano Sayarath; Leanne de Koning; Thierry Dubois; Jian-Sheng Sun; Marie Dutreix
Journal:  J Biol Chem       Date:  2012-01-23       Impact factor: 5.157

Review 2.  The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax.

Authors:  Aaron A Goodarzi; Penny Jeggo; Markus Lobrich
Journal:  DNA Repair (Amst)       Date:  2010-10-30

3.  Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair.

Authors:  Laura Spagnolo; Angel Rivera-Calzada; Laurence H Pearl; Oscar Llorca
Journal:  Mol Cell       Date:  2006-05-19       Impact factor: 17.970

4.  PARP-3 and APLF function together to accelerate nonhomologous end-joining.

Authors:  Stuart L Rulten; Anna E O Fisher; Isabelle Robert; Maria C Zuma; Michele Rouleau; Limei Ju; Guy Poirier; Bernardo Reina-San-Martin; Keith W Caldecott
Journal:  Mol Cell       Date:  2011-01-07       Impact factor: 17.970

5.  Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair.

Authors:  Michal Malewicz; Banafsheh Kadkhodaei; Nigel Kee; Nikolaos Volakakis; Ulf Hellman; Kristina Viktorsson; Chuen Yan Leung; Benjamin Chen; Rolf Lewensohn; Dik C van Gent; David J Chen; Thomas Perlmann
Journal:  Genes Dev       Date:  2011-10-01       Impact factor: 11.361

6.  Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus.

Authors:  Parimal Karmakar; Carey M Snowden; Dale A Ramsden; Vilhelm A Bohr
Journal:  Nucleic Acids Res       Date:  2002-08-15       Impact factor: 16.971

7.  The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit.

Authors:  D W Chan; S P Lees-Miller
Journal:  J Biol Chem       Date:  1996-04-12       Impact factor: 5.157

8.  The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen.

Authors:  T M Gottlieb; S P Jackson
Journal:  Cell       Date:  1993-01-15       Impact factor: 41.582

9.  The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks.

Authors:  Joanna I Loizou; Sherif F El-Khamisy; Anastasia Zlatanou; David J Moore; Douglas W Chan; Jun Qin; Stefania Sarno; Flavio Meggio; Lorenzo A Pinna; Keith W Caldecott
Journal:  Cell       Date:  2004-04-02       Impact factor: 41.582

10.  A human XRCC4-XLF complex bridges DNA.

Authors:  Sara N Andres; Alexandra Vergnes; Dejan Ristic; Claire Wyman; Mauro Modesti; Murray Junop
Journal:  Nucleic Acids Res       Date:  2012-01-27       Impact factor: 16.971
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  142 in total

Review 1.  The DNA damage-induced cell death response: a roadmap to kill cancer cells.

Authors:  Sonja Matt; Thomas G Hofmann
Journal:  Cell Mol Life Sci       Date:  2016-01-20       Impact factor: 9.261

Review 2.  Pharmacological methods to transcriptionally modulate double-strand break DNA repair.

Authors:  Alanna R Kaplan; Peter M Glazer
Journal:  Int Rev Cell Mol Biol       Date:  2019-12-18       Impact factor: 6.813

3.  Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability.

Authors:  Bo Zhao; Wei-Dao Zhang; Ying-Liang Duan; Yong-Qing Lu; Yi-Xian Cun; Chao-Hui Li; Kun Guo; Wen-Hui Nie; Lei Li; Rugang Zhang; Ping Zheng
Journal:  Cell Stem Cell       Date:  2015-04-30       Impact factor: 24.633

4.  HIV-1 infection renders brain vascular pericytes susceptible to the extracellular glutamate.

Authors:  Dorota Piekna-Przybylska; Kavyasri Nagumotu; Danielle M Reid; Sanjay B Maggirwar
Journal:  J Neurovirol       Date:  2018-11-06       Impact factor: 2.643

Review 5.  Activation and regulation of DNA-driven immune responses.

Authors:  Søren R Paludan
Journal:  Microbiol Mol Biol Rev       Date:  2015-06       Impact factor: 11.056

6.  Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair.

Authors:  Dylan A Reid; Sarah Keegan; Alejandra Leo-Macias; Go Watanabe; Natasha T Strande; Howard H Chang; Betul Akgol Oksuz; David Fenyo; Michael R Lieber; Dale A Ramsden; Eli Rothenberg
Journal:  Proc Natl Acad Sci U S A       Date:  2015-05-04       Impact factor: 11.205

7.  PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer.

Authors:  Andrä Brunner; Aldwin Suryo Rahmanto; Henrik Johansson; Marcela Franco; Johanna Viiliäinen; Mohiuddin Gazi; Oliver Frings; Erik Fredlund; Charles Spruck; Janne Lehtiö; Juha K Rantala; Lars-Gunnar Larsson; Olle Sangfelt
Journal:  Elife       Date:  2020-07-06       Impact factor: 8.140

8.  Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining.

Authors:  Wenxia Jiang; Jennifer L Crowe; Xiangyu Liu; Satoshi Nakajima; Yunyue Wang; Chen Li; Brian J Lee; Richard L Dubois; Chao Liu; Xiaochun Yu; Li Lan; Shan Zha
Journal:  Mol Cell       Date:  2015-03-26       Impact factor: 17.970

9.  The DNA-PK Inhibitor VX-984 Enhances the Radiosensitivity of Glioblastoma Cells Grown In Vitro and as Orthotopic Xenografts.

Authors:  Cindy R Timme; Barbara H Rath; John W O'Neill; Kevin Camphausen; Philip J Tofilon
Journal:  Mol Cancer Ther       Date:  2018-03-16       Impact factor: 6.261

10.  The purine scaffold Hsp90 inhibitor PU-H71 sensitizes cancer cells to heavy ion radiation by inhibiting DNA repair by homologous recombination and non-homologous end joining.

Authors:  Younghyun Lee; Huizi Keiko Li; Aya Masaoka; Shigeaki Sunada; Hirokazu Hirakawa; Akira Fujimori; Jac A Nickoloff; Ryuichi Okayasu
Journal:  Radiother Oncol       Date:  2016-09-22       Impact factor: 6.280
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