Literature DB >> 2468077

Transfer RNA is cleaved by activated bleomycin.

R S Magliozzo1, J Peisach, M R Ciriolo.   

Abstract

Activated bleomycin is shown for the first time to cleave tRNA in a specific and dose-dependent manner. Adenine and uracil are released in the reaction. Bleomycin and Fe(III)-bleomycin bind to yeast tRNAPhe) in analogy with the known behavior of the drug with B-DNA.

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Year:  1989        PMID： 2468077

Source DB:  PubMed          Journal:  Mol Pharmacol        ISSN： 0026-895X            Impact factor:   4.436


  10 in total

1.  Catalytic mechanism of bleomycin N-acetyltransferase proposed on the basis of its crystal structure.

Authors:  Kosuke Oda; Yasuyuki Matoba; Masafumi Noda; Takanori Kumagai; Masanori Sugiyama
Journal:  J Biol Chem       Date:  2009-11-03       Impact factor: 5.157

2.  Effects of hypoxanthine substitution on bleomycin-mediated DNA strand degradation in DNA-RNA hybrids.

Authors:  M Bansal; J Stubbe; J W Kozarich
Journal:  Nucleic Acids Res       Date:  1997-05-01       Impact factor: 16.971

3.  Reactivity of Nucleic Acid Radicals.

Authors:  Marc M Greenberg
Journal:  Adv Phys Org Chem       Date:  2016       Impact factor: 2.833

4.  Mechanistic analyses of site-specific degradation in DNA-RNA hybrids by prototypic DNA cleavers.

Authors:  M Bansal; J S Lee; J Stubbe; J W Kozarich
Journal:  Nucleic Acids Res       Date:  1997-05-01       Impact factor: 16.971

5.  Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor properties.

Authors:  Mattia Poletto; Matilde C Malfatti; Dorjbal Dorjsuren; Pasqualina L Scognamiglio; Daniela Marasco; Carlo Vascotto; Ajit Jadhav; David J Maloney; David M Wilson; Anton Simeonov; Gianluca Tell
Journal:  Mol Carcinog       Date:  2015-04-11       Impact factor: 4.784

6.  Site-specific cleavage of RNA by Fe(II).bleomycin.

Authors:  B J Carter; E de Vroom; E C Long; G A van der Marel; J H van Boom; S M Hecht
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

7.  Fe.bleomycin as a probe of RNA conformation.

Authors:  C E Holmes; A T Abraham; S M Hecht; C Florentz; R Giegé
Journal:  Nucleic Acids Res       Date:  1996-09-01       Impact factor: 16.971

Review 8.  The Interaction of the Metallo-Glycopeptide Anti-Tumour Drug Bleomycin with DNA.

Authors:  Vincent Murray; Jon K Chen; Long H Chung
Journal:  Int J Mol Sci       Date:  2018-05-04       Impact factor: 5.923

9.  Importance of Metal-Ion Exchange for the Biological Activity of Coordination Complexes of the Biomimetic Ligand N4Py.

Authors:  Arjan Geersing; Nathalie Ségaud; Monique G P van der Wijst; Marianne G Rots; Gerard Roelfes
Journal:  Inorg Chem       Date:  2018-06-19       Impact factor: 5.165

Review 10.  Targeting RNA structures with small molecules.

Authors:  Jessica L Childs-Disney; Xueyi Yang; Quentin M R Gibaut; Yuquan Tong; Robert T Batey; Matthew D Disney
Journal:  Nat Rev Drug Discov       Date:  2022-08-08       Impact factor: 112.288
  10 in total

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