Literature DB >> 24680436

GPCR signaling along the endocytic pathway.

Roshanak Irannejad1, Mark von Zastrow2.   

Abstract

Many G protein-coupled receptors (GPCRs) internalize after agonist-induced activation. While endocytosis has long been associated with homeostatic attenuation of cellular responsiveness, accumulating evidence from study of a wide range of eukaryotes reveals that the endocytic pathway also contributes to generating receptor-initiated signals themselves. Here we review recent progress in this area, discussing primarily but not exclusively GPCR signaling in mammalian cells.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID: 24680436      PMCID: PMC4968408          DOI: 10.1016/j.ceb.2013.10.003

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN: 0955-0674            Impact factor:   8.382


  47 in total

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  85 in total

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Review 5.  G protein-coupled receptor (GPCR) signaling via heterotrimeric G proteins from endosomes.

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Review 6.  Barcoding of GPCR trafficking and signaling through the various trafficking roadmaps by compartmentalized signaling networks.

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Review 7.  The GAPs, GEFs, GDIs and…now, GEMs: New kids on the heterotrimeric G protein signaling block.

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8.  Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief.

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