| Literature DB >> 24680436 |
Roshanak Irannejad1, Mark von Zastrow2.
Abstract
Many G protein-coupled receptors (GPCRs) internalize after agonist-induced activation. While endocytosis has long been associated with homeostatic attenuation of cellular responsiveness, accumulating evidence from study of a wide range of eukaryotes reveals that the endocytic pathway also contributes to generating receptor-initiated signals themselves. Here we review recent progress in this area, discussing primarily but not exclusively GPCR signaling in mammalian cells.Entities:
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Year: 2013 PMID: 24680436 PMCID: PMC4968408 DOI: 10.1016/j.ceb.2013.10.003
Source DB: PubMed Journal: Curr Opin Cell Biol ISSN: 0955-0674 Impact factor: 8.382