Literature DB >> 24678935

The potential of microRNAs as biofluid markers of neurodegenerative diseases--a systematic review.

Pia B Danborg1, Anja H Simonsen, Gunhild Waldemar, Niels H H Heegaard.   

Abstract

MicroRNAs (miRNA) are biological molecules transcribed from non-protein coding regions of the genome, participating in regulating cellular processes. MiRNAs in biofluids may possess neurodegenerative disease biomarker potential for screening tests, differential diagnosis and disease progression monitoring. This systematic review clarifies biomarker potential of miRNAs detected in biofluids of neurodegenerative disease patients. Thirty-three and ten miRNAs displayed significant expression between patients with multiple sclerosis and Alzheimer's disease, respectively, compared to healthy controls in minimum two studies. Thirty-eight miRNAs showed biomarker potential by distinguishing significantly between minimum two diseases. Summarized data directs future research towards discovering new biomarkers for neurodegenerative diseases.

Entities:  

Keywords:  Alzheimer’s disease; Parkinson’s disease; amyotrophic lateral sclerosis; biofluid markers; microRNA; multiple sclerosis

Mesh：

Substances：

Year:  2014        PMID： 24678935     DOI： 10.3109/1354750X.2014.904001

Source DB:  PubMed          Journal:  Biomarkers        ISSN： 1354-750X            Impact factor:   2.658


  22 in total

1.  Does SCFD1 rs10139154 Polymorphism Decrease Alzheimer's Disease Risk?

Authors:  Polyxeni Stamati; Vasileios Siokas; Athina-Maria Aloizou; Emmanouil Karampinis; Stylianos Arseniou; Valerii N Rakitskii; Aristidis Tsatsakis; Demetrios A Spandidos; Illana Gozes; Panayiotis D Mitsias; Dimitrios P Bogdanos; Georgios M Hadjigeorgiou; Efthimios Dardiotis
Journal:  J Mol Neurosci       Date:  2019-07-02       Impact factor: 3.444

2.  Plasma miR-34a-5p and miR-545-3p as Early Biomarkers of Alzheimer's Disease: Potential and Limitations.

Authors:  Marta Cosín-Tomás; Anna Antonell; Albert Lladó; Daniel Alcolea; Juan Fortea; Mario Ezquerra; Albert Lleó; Maria José Martí; Mercè Pallàs; Raquel Sanchez-Valle; José Luís Molinuevo; Coral Sanfeliu; Perla Kaliman
Journal:  Mol Neurobiol       Date:  2016-09-08       Impact factor: 5.590

3.  Inverse correlation of expression of microRNA-140-5p with progression of multiple sclerosis and differentiation of encephalitogenic T helper type 1 cells.

Authors:  Hongbing Guan; Udai P Singh; Roshni Rao; Davit Mrelashvili; Souvik Sen; Haiping Hao; Elizabeth E Zumbrun; Narendra P Singh; Prakash S Nagarkatti; Mitzi Nagarkatti
Journal:  Immunology       Date:  2016-02-17       Impact factor: 7.397

4.  Wide Profiling of Circulating MicroRNAs in Spinocerebellar Ataxia Type 7.

Authors:  Verónica M Borgonio-Cuadra; Claudia Valdez-Vargas; Sandra Romero-Córdoba; Alfredo Hidalgo-Miranda; Yessica Tapia-Guerrero; César M Cerecedo-Zapata; Oscar Hernández-Hernández; Bulmaro Cisneros; Jonathan J Magaña
Journal:  Mol Neurobiol       Date:  2019-02-05       Impact factor: 5.590

5.  Circulating microRNAs disclose biology of normal cognitive function in healthy elderly people - a discovery twin study.

Authors:  Jonas Mengel-From; Søren Feddersen; Ulrich Halekoh; Niels H H Heegaard; Matt McGue; Kaare Christensen; Qihua Tan; Lene Christiansen
Journal:  Eur J Hum Genet       Date:  2018-05-02       Impact factor: 4.246

Review 6.  Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents.

Authors:  Xiaohuan Xia; Yi Wang; Yunlong Huang; Han Zhang; Hongfang Lu; Jialin C Zheng
Journal:  Prog Neurobiol       Date:  2019-09-19       Impact factor: 11.685

Review 7.  miRNAs as Circulating Biomarkers for Alzheimer's Disease and Parkinson's Disease.

Authors:  Gohar Mushtaq; Nigel H Greig; Firoz Anwar; Mazin A Zamzami; Hani Choudhry; Munvar M Shaik; Ian A Tamargo; Mohammad A Kamal
Journal:  Med Chem       Date:  2016       Impact factor: 2.745

8.  Folic Acid Protected Neural Cells Against Aluminum-Maltolate-Induced Apoptosis by Preventing miR-19 Downregulation.

Authors:  Mingming Zhu; Bingfei Li; Xiao Ma; Cong Huang; Rui Wu; Weiwei Zhu; Xiaoting Li; Zhaofeng Liang; Feifei Deng; Jianyun Zhu; Wei Xie; Xue Yang; Ye Jiang; Shijia Wang; Jieshu Wu; Shanshan Geng; Chunfeng Xie; Caiyun Zhong; Haiyan Liu
Journal:  Neurochem Res       Date:  2016-04-25       Impact factor: 3.996

9.  Identifying Key MicroRNA Signatures for Neurodegenerative Diseases With Machine Learning Methods.

Authors:  ZhanDong Li; Wei Guo; ShiJian Ding; Lei Chen; KaiYan Feng; Tao Huang; Yu-Dong Cai
Journal:  Front Genet       Date:  2022-04-21       Impact factor: 4.772

Review 10.  microRNA-Based Biomarkers and the Diagnosis of Alzheimer's Disease.

Authors:  Yuhai Zhao; Surjyadipta Bhattacharjee; Prerna Dua; Peter N Alexandrov; Walter J Lukiw
Journal:  Front Neurol       Date:  2015-07-13       Impact factor: 4.003
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