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Literature DB >> 24678057

Bioreducible polycations in nucleic acid delivery: past, present, and future trends.

Abstract

Polycations that are degradable by reduction of disulfide bonds are developed for applications in delivery of nucleic acids. This Feature Article surveys methods of synthesis of bioreducible polycations and discusses current understanding of the mechanism of action of bioreducible polyplexes. Emphasis is placed on the relationship between the biological redox environment and toxicity, trafficking, transfection activity, and in vivo behavior of bioreducible polycations and polyplexes.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: bioreducible; disulfides; gene delivery; polycations; polyplexes

Mesh：

Substances：

Year: 2014 PMID： 24678057 PMCID： PMC4410047 DOI： 10.1002/mabi.201400061

Source DB: PubMed Journal: Macromol Biosci ISSN： 1616-5187 Impact factor: 4.979

146 in total

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Authors: Wenchao Sun; Pamela B Davis
Journal: J Control Release Date: 2010-05-12 Impact factor: 9.776

2. Tuning the mechanical properties of bioreducible multilayer films for improved cell adhesion and transfection activity.

Authors: Jenifer Blacklock; Andreas Vetter; Andreas Lankenau; David Oupický; Helmuth Möhwald
Journal: Biomaterials Date: 2010-06-26 Impact factor: 12.479

3. Reduction of disulfide bonds within lysosomes is a key step in antigen processing.

Authors: D S Collins; E R Unanue; C V Harding
Journal: J Immunol Date: 1991-12-15 Impact factor: 5.422

4. Novel bioreducible poly(amido amine)s for highly efficient gene delivery.

Authors: Chao Lin; Zhiyuan Zhong; Martin C Lok; Xulin Jiang; Wim E Hennink; Jan Feijen; Johan F J Engbersen
Journal: Bioconjug Chem Date: 2007 Jan-Feb Impact factor: 4.774

5. Physical and functional sensitivity of zinc finger transcription factors to redox change.

Authors: X Wu; N H Bishopric; D J Discher; B J Murphy; K A Webster
Journal: Mol Cell Biol Date: 1996-03 Impact factor: 4.272

6. Suicide gene therapy using reducible poly (oligo-D-arginine) for the treatment of spinal cord tumors.

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Journal: Biomaterials Date: 2011-09-15 Impact factor: 12.479

7. Comparison of lipoic and asparagusic acid for surface-initiated disulfide-exchange polymerization.

Authors: Alessio Carmine; Yuya Domoto; Naomi Sakai; Stefan Matile
Journal: Chemistry Date: 2013-07-25 Impact factor: 5.236

8. Peptide-matrix-mediated gene transfer of an oxygen-insensitive hypoxia-inducible factor-1alpha variant for local induction of angiogenesis.

Authors: Diana Trentin; Heike Hall; Sandra Wechsler; Jeffrey A Hubbell
Journal: Proc Natl Acad Sci U S A Date: 2006-02-13 Impact factor: 11.205

Review 9. Cell signalling and the glutathione redox system.

Authors: Giuseppe Filomeni; Giuseppe Rotilio; Maria Rosa Ciriolo
Journal: Biochem Pharmacol Date: 2002-09 Impact factor: 5.858

10. Arginine-grafted bioreducible poly(disulfide amine) for gene delivery systems.

Authors: Tae-il Kim; Mei Ou; Minhyung Lee; Sung Wan Kim
Journal: Biomaterials Date: 2008-11-12 Impact factor: 12.479

21 in total

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Journal: Macromol Biosci Date: 2017-08-04 Impact factor: 4.979

2. Self-immolative nanoparticles for simultaneous delivery of microRNA and targeting of polyamine metabolism in combination cancer therapy.

Authors: Ying Xie; Tracy Murray-Stewart; Yazhe Wang; Fei Yu; Jing Li; Laurence J Marton; Robert A Casero; David Oupický
Journal: J Control Release Date: 2016-12-23 Impact factor: 9.776

3. Thiol-Disulfide Exchange as a Route for Endosomal Escape of Polymeric Nanoparticles.

Authors: Pintu Kanjilal; Kingshuk Dutta; S Thayumanavan
Journal: Angew Chem Int Ed Engl Date: 2022-08-08 Impact factor: 16.823

4. Pnictogen-Centered Cascade Exchangers for Thiol-Mediated Uptake: As(III)-, Sb(III)-, and Bi(III)-Expanded Cyclic Disulfides as Inhibitors of Cytosolic Delivery and Viral Entry.

Authors: Bumhee Lim; Takehiro Kato; Celine Besnard; Amalia I Poblador Bahamonde; Naomi Sakai; Stefan Matile
Journal: JACS Au Date: 2022-03-24