OBJECTIVE: The objective of this study was to investigate changes in volatile organic compounds (VOCs) in exhaled breath in overweight/obese children compared with their lean counterparts. STUDY DESIGN: Single exhaled breath was collected and analyzed per protocol using selective ion flow tube mass spectrometry (SIFT-MS). RESULTS: Sixty overweight/obese children and 55 lean controls were included. Compared with the lean group, the obese group was significantly older (14.1 ± 2.8 vs. 12.1 ± 3.0 years), taller (164.8 ± 10.9 vs. 153.3 ± 17.1 cm) and more likely to be Caucasian (60% vs. 35.2%); P < 0.05 for all. A comparison of the SIFT-MS results of the obese group with the lean group revealed differences in concentration of more than 50 compounds. A panel of four VOCs can identify the presence of overweight/obesity with excellent accuracy. Further analysis revealed that breath isoprene, 1-decene, 1-octene, ammonia and hydrogen sulfide were significantly higher in the obese group compared with the lean group (P value < 0.01 for all). CONCLUSION: Obese children have a unique pattern of exhaled VOCs. Changes in VOCs observed in this study may help to gain insight into pathophysiological processes and pathways leading to the development of childhood obesity.
OBJECTIVE: The objective of this study was to investigate changes in volatile organic compounds (VOCs) in exhaled breath in overweight/obesechildren compared with their lean counterparts. STUDY DESIGN: Single exhaled breath was collected and analyzed per protocol using selective ion flow tube mass spectrometry (SIFT-MS). RESULTS: Sixty overweight/obesechildren and 55 lean controls were included. Compared with the lean group, the obese group was significantly older (14.1 ± 2.8 vs. 12.1 ± 3.0 years), taller (164.8 ± 10.9 vs. 153.3 ± 17.1 cm) and more likely to be Caucasian (60% vs. 35.2%); P < 0.05 for all. A comparison of the SIFT-MS results of the obese group with the lean group revealed differences in concentration of more than 50 compounds. A panel of four VOCs can identify the presence of overweight/obesity with excellent accuracy. Further analysis revealed that breath isoprene, 1-decene, 1-octene, ammonia and hydrogen sulfide were significantly higher in the obese group compared with the lean group (P value < 0.01 for all). CONCLUSION:Obesechildren have a unique pattern of exhaled VOCs. Changes in VOCs observed in this study may help to gain insight into pathophysiological processes and pathways leading to the development of childhood obesity.
Authors: R J Kuczmarski; C L Ogden; L M Grummer-Strawn; K M Flegal; S S Guo; R Wei; Z Mei; L R Curtin; A F Roche; C L Johnson Journal: Adv Data Date: 2000-06-08
Authors: Piia Simonen; Anna Kotronen; Maarit Hallikainen; Ksenia Sevastianova; Janne Makkonen; Antti Hakkarainen; Nina Lundbom; Tatu A Miettinen; Helena Gylling; Hannele Yki-Järvinen Journal: J Hepatol Date: 2010-08-22 Impact factor: 25.083
Authors: Betty K Hamilton; Lisa A Rybicki; David Grove; Christina Ferraro; Jamie Starn; Brittany Hodgeman; Jamie Elberson; Victoria Winslow; Donna Corrigan; Aaron T Gerds; Rabi Hanna; Matt E Kalaycio; Ronald M Sobecks; Navneet S Majhail; Raed A Dweik Journal: Blood Adv Date: 2019-09-24
Authors: Jarrod W Barnes; Adriano R Tonelli; Gustavo A Heresi; Jennie E Newman; Noël E Mellor; David E Grove; Raed A Dweik Journal: Pulm Circ Date: 2016-12 Impact factor: 3.017
Authors: Daniel J C Berkhout; Hendrik J Niemarkt; Marc A Benninga; Andries E Budding; Anton H van Kaam; Boris W Kramer; Charlene M Pantophlet; Mirjam M van Weissenbruch; Nanne K H de Boer; Tim G J de Meij Journal: Pediatr Res Date: 2017-11-22 Impact factor: 3.756
Authors: Rohit Sinha; Khalida A Lockman; Natalie Z M Homer; Edward Bower; Paul Brinkman; Hugo H Knobel; Jonathan A Fallowfield; Alan J Jaap; Peter C Hayes; John N Plevris Journal: JHEP Rep Date: 2020-06-15
Authors: Rosa A Sola Martínez; José M Pastor Hernández; Óscar Yanes Torrado; Manuel Cánovas Díaz; Teresa de Diego Puente; María Vinaixa Crevillent Journal: Pediatr Res Date: 2020-09-12 Impact factor: 3.756