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Literature DB >> 24677528

A simple strategy for glycosyltransferase-catalyzed aminosugar nucleotide synthesis.

Jianjun Zhang, Shanteri Singh, Ryan R Hughes, Maoquan Zhou, Manjula Sunkara, Andrew J Morris, Jon S Thorson.

Abstract

A set of 2-chloro-4-nitrophenyl glucosamino-/xylosaminosides were synthesized and assessed as potential substrates in the context of glycosyltransferase-catalyzed formation of the corresponding UDP/TDP-α-D-glucosamino-/xylosaminosugars and in single-vessel model transglycosylation reactions. This study highlights a robust platform for aminosugar nucleotide synthesis and reveals OleD Loki to be a proficient catalyst for U/TDP-aminosugar synthesis and utilization

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Year: 2014 PMID： 24677528 PMCID： PMC4051237 DOI： 10.1002/cbic.201300779

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

67 in total

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4. Carbohydrate Metabolism in Bacteria: Alternative Specificities in ADP-Glucose Pyrophosphorylases Open Novel Metabolic Scenarios and Biotechnological Tools.

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