Literature DB >> 21322610

Probing the role of the mycosamine C2'-OH on the activity of amphotericin B.

Mitchell P Croatt1, Erick M Carreira.   

Abstract

A synthetic route to a mycosamine donor was designed and provided access to a set of AmB derivatives targeted to probe the effect of the C2'-OH. It was determined that the configuration of the C2'-position is inconsequential but that O-methylation of this alcohol was deleterious to its mode of action. Additionally, the analog incorporating a mycosamine derivative from the enantiomeric series was devoid of activity.

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Year:  2011        PMID： 21322610     DOI： 10.1021/ol2000765

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


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