Literature DB >> 24676965

Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD.

Cleo L Crunelle1, Wim van den Brink1, Geert Dom1, Jan Booij1.   

Abstract

Impulsivity is a multidimensional construct, including impulsive decision-making and impulsive action, representing relatively independent neurocircuitries. ADHD is treated with methylphenidate, a drug that binds to dopamine transporters. This study in 24 adult male patients with ADHD shows that dopamine transporter occupancy by methylphenidate in the putamen correlates with improvements in cognitive but not in motor impulsivity. Royal College of Psychiatrists.

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Year:  2014        PMID： 24676965     DOI： 10.1192/bjp.bp.113.132977

Source DB:  PubMed          Journal:  Br J Psychiatry        ISSN： 0007-1250            Impact factor:   9.319


  4 in total

1.  Dissociable roles of dopamine and serotonin transporter function in a rat model of negative urgency.

Authors:  Justin R Yates; Mahesh Darna; Cassandra D Gipson; Linda P Dwoskin; Michael T Bardo
Journal:  Behav Brain Res       Date:  2015-05-21       Impact factor: 3.332

2.  PharmGKB summary: methylphenidate pathway, pharmacokinetics/pharmacodynamics.

Authors:  Tyler Stevens; Katrin Sangkuhl; Jacob T Brown; Russ B Altman; Teri E Klein
Journal:  Pharmacogenet Genomics       Date:  2019-08       Impact factor: 2.089

3.  Delay Aversion and Executive Functioning in Adults With Attention-Deficit/Hyperactivity Disorder: Before and After Stimulant Treatment.

Authors:  Ann-Marie Low; Julijana le Sommer; Signe Vangkilde; Birgitte Fagerlund; Birte Glenthøj; Edmund Sonuga-Barke; Thomas Habekost; Jens Richardt Møllegaard Jepsen
Journal:  Int J Neuropsychopharmacol       Date:  2018-11-01       Impact factor: 5.176

4.  Individual Differences in Dopamine Are Associated with Reward Discounting in Clinical Groups But Not in Healthy Adults.

Authors:  Jaime J Castrellon; Kendra L Seaman; Jennifer L Crawford; Jacob S Young; Christopher T Smith; Linh C Dang; Ming Hsu; Ronald L Cowan; David H Zald; Gregory R Samanez-Larkin
Journal:  J Neurosci       Date:  2018-11-16       Impact factor: 6.167
  4 in total

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