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Literature DB >> 2467301

Early gene regulation by nerve growth factor in PC12 cells: induction of an interferon-related gene.

Abstract

Nerve growth factor (NGF) induces the chromaffin cell line PC12 to differentiate into cells with many of the properties of sympathetic neurons. We investigated the early differentiative phase and identified a gene, PC4, rapidly and transiently induced by NGF in PC12 cells. PC4 cDNA is homologous to the partial sequence of a putative mouse beta-interferon and encodes a protein related to a lymphokine, the rat gamma-interferon protein. Nonetheless, PC4 appears devoid of antiviral activity. PC4 is expressed in proliferating and differentiating tissues, such as amnion, placenta, and brain at embryonic day 13.5. The relationship of PC4 to interferons and lymphokines suggests that it could play a role in regulating gene activity in the pathways induced by NGF.

Entities: Chemical Gene Species

Mesh：

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Year: 1989 PMID： 2467301 PMCID： PMC286853 DOI： 10.1073/pnas.86.6.2088

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

37 in total

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27 in total

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Authors: Mara D'Onofrio; Francesca Paoletti; Ivan Arisi; Rossella Brandi; Francesca Malerba; Luisa Fasulo; Antonino Cattaneo
Journal: PLoS One Date: 2011-06-03 Impact factor: 3.240

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Journal: Neurochem Res Date: 2008-09-10 Impact factor: 3.996