Literature DB >> 24668337

Dinuclear zinc(II) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation.

Qiang Xie1, Shenggui Liu, Xiaoling Li, Qiong Wu, Zuandi Luo, Xiaoyan Fu, Wenqiang Cao, Guoqiang Lan, Dan Li, Wenjie Zheng, Tianfeng Chen.   

Abstract

Herein we demonstrated that dinuclear zinc complexes could overcome drug resistance in R-HepG2 drug resistance hepatocellular carcinoma cells through induction of mitochondria-mediated apoptosis or by triggering mitochondria fragmentation, depletion of the membrane potential and intracellular ATP levels.

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Year:  2014        PMID： 24668337     DOI： 10.1039/c4dt00198b

Source DB:  PubMed          Journal:  Dalton Trans        ISSN： 1477-9226            Impact factor:   4.390


  3 in total

1.  Structure of the mercury(II) mixed-halide (Br/Cl) complex of 2,2'-(5-tert-butyl-1,3-phenyl-ene)bis-(1-pentyl-1H-benzo[d]imidazole).

Authors:  Varsha Rani; Harkesh B Singh; Ray J Butcher
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-02-21

2.  Synthesis and structure of the mercury chloride complex of 2,2'-(2-bromo-5-tert-butyl-1,3-phenyl-ene)bis-(1-methyl-1H-benzimidazole).

Authors:  Varsha Rani; Harkesh B Singh; Ray J Butcher
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-02-10

3.  Structure of 2,2'-(5-tert-butyl-1,3-phenyl-ene)bis-(1-pentyl-1H-benzimidazol-3-ium) tetra-chlorido-mercurate(II).

Authors:  Varsha Rani; Harkesh B Singh; Ray J Butcher
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-03-24
  3 in total

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