| Literature DB >> 24661721 |
Michael Badowski1, Christopher L Shultz1, Yvette Eason1, Nafees Ahmad1, David T Harris2.
Abstract
Sex and age-matched wild-type and TCR transgenic mice were infected with cytomegalovirus (CMV) at 6 months of age and followed for 12 additional months to examine aging of the immune system. It was found that viral infection of C57Bl/6 mice resulted in accelerated aging of the immune system as shown by a loss of CD8(+)28(+) cells and an accumulation of KLRG1(+) T cells. CMV infection of OT-1 transgenic mice had no influence on immune aging of these mice which nonetheless demonstrated an accumulation of CD8(+)28(-) and KLRG1(+) T cells with time. CD4(+) T cells were unaffected in either strain of mice. Thus, immunological aging was found to be due to both cell-intrinsic and cell-extrinsic factors. Persistent viral infections may accelerate immunological aging but consideration must be given to individual variation in the aging process.Entities:
Keywords: Aging; Immunity; MCMV; Mice; OT-1
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Year: 2014 PMID： 24661721 PMCID： PMC4004698 DOI： 10.1016/j.imbio.2014.02.008
Source DB: PubMed Journal: Immunobiology ISSN： 0171-2985 Impact factor: 3.144