| Literature DB >> 24659482 |
Wei-Guang Zhang, Shu-Ying Zhu, Xiao-Juan Bai, De-Long Zhao, Shi-Min Jian, Juan Li, Zuo-Xiang Li, Bo Fu, Guang-Yan Cai, Xue-Feng Sun, Xiang-Mei Chen.
Abstract
The purpose of this study is to build a biological age (BA) equation combining telomere length with chronological age (CA) and associated aging biomarkers. In total, 139 healthy volunteers were recruited from a Chinese Han cohort in Beijing. A genetic index, renal function indices, cardiovascular function indices, brain function indices, and oxidative stress and inflammation indices (C-reactive protein [CRP]) were measured and analyzed. A BA equation was proposed based on selected parameters, with terminal telomere restriction fragment (TRF) and CA as the two principal components. The selected aging markers included mitral annulus peak E anterior wall (MVEA), intima-media thickness (IMT), cystatin C (CYSC), D-dimer (DD), and digital symbol test (DST). The BA equation was: BA = −2.281TRF + 26.321CYSC + 0.025DD − 104.419MVEA + 34.863IMT − 0.265DST + 0.305CA + 26.346. To conclude, telomere length and CA as double benchmarks may be a new method to build a BA.Entities:
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Year: 2014 PMID： 24659482 PMCID： PMC4082565 DOI： 10.1007/s11357-014-9639-y
Source DB: PubMed Journal: Age (Dordr) ISSN： 0161-9152