Literature DB >> 2465913

Hemoglobin causes both endothelium-dependent and endothelium-independent contraction of the pig coronary arteries, independently of an inhibition of EDRF effects.

J L Bény1, P C Brunet, V Van der Bent.   

Abstract

Hemoglobin is widely used as an inhibitor of EDRF effects. Hemoglobin contracts pig coronary arteries in vitro. However, during this contraction, effects of substance P and bradykinin which act via the EDRF are not inhibited. This means that the hemoglobin contraction is not caused by inhibition of the EDRF. This contraction is caused by a substance released from the endothelium, and by eicosanoïds released from the smooth muscles.

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Year:  1989        PMID： 2465913     DOI： 10.1007/bf01954846

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  15 in total

1.  A novel potent vasoconstrictor peptide produced by vascular endothelial cells.

Authors:  M Yanagisawa; H Kurihara; S Kimura; Y Tomobe; M Kobayashi; Y Mitsui; Y Yazaki; K Goto; T Masaki
Journal:  Nature       Date:  1988-03-31       Impact factor: 49.962

2.  Role of endothelium in haemoglobin-induced contraction of dog basilar artery.

Authors:  H E Connor; W Feniuk
Journal:  Eur J Pharmacol       Date:  1987-08-04       Impact factor: 4.432

3.  Endothelial cell morphology in focal areas of in vivo Evans blue uptake in the young pig aorta. I. Quantitative light microscopic findings.

Authors:  B A Caplan; R G Gerrity; C J Schwartz
Journal:  Exp Mol Pathol       Date:  1974-08       Impact factor: 3.362

4.  Everted portal vein: a sensitive model for studies of vasoactive compounds.

Authors:  D Mastrangelo; R Mathison
Journal:  J Cardiovasc Pharmacol       Date:  1983 Jan-Feb       Impact factor: 3.105

5.  Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.

Authors:  W Martin; G M Villani; D Jothianandan; R F Furchgott
Journal:  J Pharmacol Exp Ther       Date:  1985-03       Impact factor: 4.030

6.  The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.

Authors:  R F Furchgott; J V Zawadzki
Journal:  Nature       Date:  1980-11-27       Impact factor: 49.962

7.  Sustained coronary vasoconstriction provoked by a peptidergic substance released from endothelial cells in culture.

Authors:  M N Gillespie; J O Owasoyo; I F McMurtry; R F O'Brien
Journal:  J Pharmacol Exp Ther       Date:  1986-02       Impact factor: 4.030

8.  Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium.

Authors:  G M Rubanyi; P M Vanhoutte
Journal:  J Physiol       Date:  1985-07       Impact factor: 5.182

9.  Dose responses of cerebral arteries of the dog, rabbit, and man to human hemoglobin in vitro.

Authors:  G R Wellum; T W Irvine; N T Zervas
Journal:  J Neurosurg       Date:  1980-10       Impact factor: 5.115

10.  Electrophysiological and mechanical effects of substance P and acetylcholine on rabbit aorta.

Authors:  J L Bény; P C Brunet
Journal:  J Physiol       Date:  1988-04       Impact factor: 5.182
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  2 in total

1.  Oxidized low density lipoproteins cause contraction and inhibit endothelium-dependent relaxation in the pig coronary artery.

Authors:  B C Simon; L D Cunningham; R A Cohen
Journal:  J Clin Invest       Date:  1990-07       Impact factor: 14.808

2.  Effect of nitro-L-arginine on endothelium-dependent hyperpolarizations and relaxations of pig coronary arteries.

Authors:  C Pacicca; P Y von der Weid; J L Beny
Journal:  J Physiol       Date:  1992-11       Impact factor: 5.182
  2 in total

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