Literature DB >> 2442009

Role of endothelium in haemoglobin-induced contraction of dog basilar artery.

H E Connor, W Feniuk.   

Abstract

Haemoglobin (10 nM-30 microM) caused contraction of dog isolated basilar artery. In preparations which were perfused with Triton X-100 (0.1%) for one min to remove the endothelium, substance P relaxation was abolished but haemoglobin-induced contractions were unchanged. Endothelium removal or damage was confirmed histologically. These results suggest that the integrity of the endothelium is not essential for haemoglobin to produce contraction in dog basilar artery.

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Year:  1987        PMID： 2442009     DOI： 10.1016/0014-2999(87)90640-6

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

1.  Investigation of the vasoconstrictor action of subarachnoid haemoglobin in the pig cerebral circulation in vivo.

Authors:  J V Byrne; T M Griffith; D H Edwards; T J Harrison; K R Johnston
Journal:  Br J Pharmacol       Date:  1989-07       Impact factor: 8.739

2.  Factors inducing endothelium-dependent relaxation in the guinea-pig basilar artery as estimated from the actions of haemoglobin.

Authors:  E Nishiye; K Nakao; T Itoh; H Kuriyama
Journal:  Br J Pharmacol       Date:  1989-03       Impact factor: 8.739

3.  Hemoglobin causes both endothelium-dependent and endothelium-independent contraction of the pig coronary arteries, independently of an inhibition of EDRF effects.

Authors:  J L Bény; P C Brunet; V Van der Bent
Journal:  Experientia       Date:  1989-02-15

4.  Evidence for the participation of vascular endothelium originated humoral factors to cerebral vasospasm.

Authors:  M K Baykaner
Journal:  Acta Neurochir (Wien)       Date:  1993       Impact factor: 2.216

5.  Influence of the endothelium on contractile effects of 5-hydroxytryptamine and selective 5-HT agonists in canine basilar artery.

Authors:  H E Connor; W Feniuk
Journal:  Br J Pharmacol       Date:  1989-01       Impact factor: 8.739

6.  Role of endothelium in hypoxic contraction of canine basilar artery.

Authors:  D A Elliott; B Y Ong; J E Bruni; D Bose
Journal:  Br J Pharmacol       Date:  1989-04       Impact factor: 8.739

7.  Relaxation of sheep cerebral arteries by vasoactive intestinal polypeptide and neurogenic stimulation: inhibition by L-NG-monomethyl arginine in endothelium-denuded vessels.

Authors:  A J Gaw; J Aberdeen; P P Humphrey; R M Wadsworth; G Burnstock
Journal:  Br J Pharmacol       Date:  1991-03       Impact factor: 8.739
  7 in total

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