Melanie C Buser1, H Edward Murray1, Franco Scinicariello2. 1. Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, GA 30341, USA. 2. Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry (ATSDR), Atlanta, GA 30341, USA. Electronic address: fes6@cdc.gov.
Abstract
BACKGROUND: Exposure to environmental chemicals may play a role in the development of obesity. Evidence suggests phthalate exposure may be associated with obesity in children and adults. OBJECTIVE: To examine the association of ten urinary phthalate metabolites mono-n-butyl phthalate (MnBP), mono-ethyl phthalate (MEP), mono-isobutyl phthalate (MiBP), mono-2-ethyl-5-carboxypentyl phthalate (MECPP), mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-2-ethylhexyl phthalate (MEHP), mono-benzyl phthalate (MBzP), mono-(carboxylnonyl) phthalate (MCNP), and mono-(carboxyoctyl) phthalate (MCOP) grouped by molecular weight of their parent compounds with body weight outcomes in children, adolescent and adult participants in the National Health and Nutrition Examination Survey (NHANES) 2007-2010. METHODS: We performed multinomial logistic regression to analyze the association between obesity and urinary phthalate metabolite concentrations in children and adolescents and adults. RESULTS: Low molecular weight (LMW) phthalate metabolites (MnBP, MEP and MiBP) are significantly (p<0.05) associated with higher odds for obesity in male children and adolescents. High molecular weight (HMW) phthalate metabolites (MECPP, MEHHP, MEOHP, MEHP, MBzP, MCNP, and MCOP) and di-2-ethylhexyl phthalate (DEHP) metabolites (MEHHP, MEOHP, MEHP and MECPP) are significantly (p<0.05) associated with higher OR for obesity in all adults. Additionally, DEHP metabolites are significantly associated with obesity in all female adults; whereas DEHP and HMW metabolites are significantly associated with OR for obesity in males 60 years and older. CONCLUSIONS: We found age and sex differences in the association between urinary phthalate metabolite concentrations and body weight outcomes. Reverse causation cannot be excluded since overweight and obese people will have more fat mass, they may store more phthalates, thus leading to higher excretion concentrations. Published by Elsevier GmbH.
BACKGROUND: Exposure to environmental chemicals may play a role in the development of obesity. Evidence suggests phthalate exposure may be associated with obesity in children and adults. OBJECTIVE: To examine the association of ten urinary phthalate metabolites mono-n-butyl phthalate (MnBP), mono-ethyl phthalate (MEP), mono-isobutyl phthalate (MiBP), mono-2-ethyl-5-carboxypentyl phthalate (MECPP), mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-2-ethylhexyl phthalate (MEHP), mono-benzyl phthalate (MBzP), mono-(carboxylnonyl) phthalate (MCNP), and mono-(carboxyoctyl) phthalate (MCOP) grouped by molecular weight of their parent compounds with body weight outcomes in children, adolescent and adult participants in the National Health and Nutrition Examination Survey (NHANES) 2007-2010. METHODS: We performed multinomial logistic regression to analyze the association between obesity and urinary phthalate metabolite concentrations in children and adolescents and adults. RESULTS: Low molecular weight (LMW) phthalate metabolites (MnBP, MEP and MiBP) are significantly (p<0.05) associated with higher odds for obesity in male children and adolescents. High molecular weight (HMW) phthalate metabolites (MECPP, MEHHP, MEOHP, MEHP, MBzP, MCNP, and MCOP) and di-2-ethylhexyl phthalate (DEHP) metabolites (MEHHP, MEOHP, MEHP and MECPP) are significantly (p<0.05) associated with higher OR for obesity in all adults. Additionally, DEHP metabolites are significantly associated with obesity in all female adults; whereas DEHP and HMW metabolites are significantly associated with OR for obesity in males 60 years and older. CONCLUSIONS: We found age and sex differences in the association between urinary phthalate metabolite concentrations and body weight outcomes. Reverse causation cannot be excluded since overweight and obesepeople will have more fat mass, they may store more phthalates, thus leading to higher excretion concentrations. Published by Elsevier GmbH.
Authors: Susan L Teitelbaum; Nancy Mervish; Erin L Moshier; Nita Vangeepuram; Maida P Galvez; Antonia M Calafat; Manori J Silva; Barbara L Brenner; Mary S Wolff Journal: Environ Res Date: 2012-01-04 Impact factor: 6.498
Authors: Moses T Bility; Jerry T Thompson; Richard H McKee; Raymond M David; John H Butala; John P Vanden Heuvel; Jeffrey M Peters Journal: Toxicol Sci Date: 2004-08-13 Impact factor: 4.849
Authors: Elizabeth E Hatch; Jessica W Nelson; M Mustafa Qureshi; Janice Weinberg; Lynn L Moore; Martha Singer; Thomas F Webster Journal: Environ Health Date: 2008-06-03 Impact factor: 5.984
Authors: Richard W Stahlhut; Edwin van Wijngaarden; Timothy D Dye; Stephen Cook; Shanna H Swan Journal: Environ Health Perspect Date: 2007-03-14 Impact factor: 9.031
Authors: Katherine W Reeves; Mary Díaz Santana; JoAnn E Manson; Susan E Hankinson; R Thomas Zoeller; Carol Bigelow; Lifang Hou; Jean Wactawski-Wende; Simin Liu; Lesley Tinker; Antonia M Calafat Journal: Environ Res Date: 2018-10-30 Impact factor: 6.498