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Literature DB >> 24656076

Chemical exchange in biomacromolecules: past, present, and future.

Abstract

The perspective reviews quantitative investigations of chemical exchange phenomena in proteins and other biological macromolecules using NMR spectroscopy, particularly relaxation dispersion methods. The emphasis is on techniques and applications that quantify the populations, interconversion kinetics, and structural features of sparsely populated conformational states in equilibrium with a highly populated ground state. Applications to folding, molecular recognition, catalysis, and allostery by proteins and nucleic acids are highlighted.

Entities: CellLine Chemical Disease Gene Mutation Species

Keywords: Dynamics; Kinetics; NMR; Nucleic acids; Proteins; Relaxation

Mesh：

Substances：

Year: 2014 PMID： 24656076 PMCID： PMC4049312 DOI： 10.1016/j.jmr.2014.01.008

Source DB: PubMed Journal: J Magn Reson ISSN： 1090-7807 Impact factor: 2.229

138 in total

1. Concerted dynamics link allosteric sites in the PBX homeodomain.

Authors: Patrick J Farber; Anthony Mittermaier
Journal: J Mol Biol Date: 2010-11-16 Impact factor: 5.469

2. Time scales of slow motions in ubiquitin explored by heteronuclear double resonance.

Authors: Nicola Salvi; Simone Ulzega; Fabien Ferrage; Geoffrey Bodenhausen
Journal: J Am Chem Soc Date: 2012-01-27 Impact factor: 15.419

3. Measurement of signs of chemical shift differences between ground and excited protein states: a comparison between H(S/M)QC and R1rho methods.

Authors: Renate Auer; D Flemming Hansen; Philipp Neudecker; Dmitry M Korzhnev; D Ranjith Muhandiram; Robert Konrat; Lewis E Kay
Journal: J Biomol NMR Date: 2009-12-22 Impact factor: 2.835

4. Measurement of the signs of methyl 13C chemical shift differences between interconverting ground and excited protein states by R(1ρ): an application to αB-crystallin.

Authors: Andrew J Baldwin; Lewis E Kay
Journal: J Biomol NMR Date: 2012-04-05 Impact factor: 2.835

5. A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis.

Authors: Gira Bhabha; Jeeyeon Lee; Damian C Ekiert; Jongsik Gam; Ian A Wilson; H Jane Dyson; Stephen J Benkovic; Peter E Wright
Journal: Science Date: 2011-04-08 Impact factor: 47.728

6. Probing chemical shifts of invisible states of proteins with relaxation dispersion NMR spectroscopy: how well can we do?

Authors: D Flemming Hansen; Pramodh Vallurupalli; Patrik Lundström; Philipp Neudecker; Lewis E Kay
Journal: J Am Chem Soc Date: 2008-02-01 Impact factor: 15.419

7. An exchange-free measure of 15N transverse relaxation: an NMR spectroscopy application to the study of a folding intermediate with pervasive chemical exchange.

Authors: D Flemming Hansen; Daiwen Yang; Haniqiao Feng; Zheng Zhou; Silke Wiesner; Yawen Bai; Lewis E Kay
Journal: J Am Chem Soc Date: 2007-08-28 Impact factor: 15.419

8. Carbonyl carbon transverse relaxation dispersion measurements and ms-micros timescale motion in a protein hydrogen bond network.

Authors: Rieko Ishima; James Baber; John M Louis; Dennis A Torchia
Journal: J Biomol NMR Date: 2004-06 Impact factor: 2.835

9. Mapping chemical exchange in proteins with MW > 50 kD.

Authors: Chunyu Wang; Mark Rance; Arthur G Palmer
Journal: J Am Chem Soc Date: 2003-07-30 Impact factor: 15.419

10. Dynamic properties of a type II cadherin adhesive domain: implications for the mechanism of strand-swapping of classical cadherins.

Authors: Vesselin Z Miloushev; Fabiana Bahna; Carlo Ciatto; Goran Ahlsen; Barry Honig; Lawrence Shapiro; Arthur G Palmer
Journal: Structure Date: 2008-08-06 Impact factor: 5.006

95 in total

1. Speeding-up exchange-mediated saturation transfer experiments by Fourier transform.

Authors: Marta G Carneiro; Jithender G Reddy; Christian Griesinger; Donghan Lee
Journal: J Biomol NMR Date: 2015-09-09 Impact factor: 2.835

2. NMR probing of invisible excited states using selectively labeled RNAs.

Authors: Regan M LeBlanc; Andrew P Longhini; Vitali Tugarinov; T Kwaku Dayie
Journal: J Biomol NMR Date: 2018-06-01 Impact factor: 2.835

3. Glutamate and Glycine Binding to the NMDA Receptor.

Authors: Alvin Yu; Albert Y Lau
Journal: Structure Date: 2018-06-07 Impact factor: 5.006

4. Confinement and Stabilization of Fyn SH3 Folding Intermediate Mimetics within the Cavity of the Chaperonin GroEL Demonstrated by Relaxation-Based NMR.

Authors: David S Libich; Vitali Tugarinov; Rodolfo Ghirlando; G Marius Clore
Journal: Biochemistry Date: 2017-02-08 Impact factor: 3.162

5. Intrinsic unfoldase/foldase activity of the chaperonin GroEL directly demonstrated using multinuclear relaxation-based NMR.

Authors: David S Libich; Vitali Tugarinov; G Marius Clore
Journal: Proc Natl Acad Sci U S A Date: 2015-06-29 Impact factor: 11.205

6. Coupling of Conformational Transitions in the N-terminal Domain of the 51-kDa FK506-binding Protein (FKBP51) Near Its Site of Interaction with the Steroid Receptor Proteins.

Authors: David M LeMaster; Sourajit M Mustafi; Matthew Brecher; Jing Zhang; Annie Héroux; Hongmin Li; Griselda Hernández
Journal: J Biol Chem Date: 2015-05-07 Impact factor: 5.157