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Literature DB >> 24655497

Does cell mechanics in adipogenesis offer new keys for the prevention and management of obesity?

Thomas Franz¹.

Abstract

Entities: Disease

Mesh：

Year: 2014 PMID： 24655497 PMCID： PMC3984985 DOI： 10.1016/j.bpj.2014.01.004

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

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9 in total

1. Adipocyte stiffness increases with accumulation of lipid droplets.

Authors: Naama Shoham; Pinhas Girshovitz; Rona Katzengold; Natan T Shaked; Dafna Benayahu; Amit Gefen
Journal: Biophys J Date: 2014-03-18 Impact factor: 4.033

2. Mechanical compressive force inhibits adipogenesis of adipose stem cells.

Authors: G Li; N Fu; X Yang; M Li; K Ba; X Wei; Y Fu; Y Yao; X Cai; Y Lin
Journal: Cell Prolif Date: 2013-08-29 Impact factor: 6.831

3. Static mechanical stretching accelerates lipid production in 3T3-L1 adipocytes by activating the MEK signaling pathway.

Authors: Naama Shoham; Ruth Gottlieb; Orna Sharabani-Yosef; Uri Zaretsky; Dafna Benayahu; Amit Gefen
Journal: Am J Physiol Cell Physiol Date: 2011-10-19 Impact factor: 4.249

4. Mechanical stretch suppresses BMP4 induction of stem cell adipogenesis via upregulating ERK but not through downregulating Smad or p38.

Authors: Jeong Soon Lee; Ligyeom Ha; Jin-Hee Park; Jung Yul Lim
Journal: Biochem Biophys Res Commun Date: 2012-01-12 Impact factor: 3.575

Does cell mechanics in adipogenesis offer new keys for the prevention and management of obesity?

1. Adipocyte stiffness increases with accumulation of lipid droplets.

2. Mechanical compressive force inhibits adipogenesis of adipose stem cells.

3. Static mechanical stretching accelerates lipid production in 3T3-L1 adipocytes by activating the MEK signaling pathway.

4. Mechanical stretch suppresses BMP4 induction of stem cell adipogenesis via upregulating ERK but not through downregulating Smad or p38.

5. Compressive force inhibits adipogenesis through COX-2-mediated down-regulation of PPARgamma2 and C/EBPalpha.

6. Inhibition of adipocyte differentiation by mechanical stretching through ERK-mediated downregulation of PPARgamma2.

7. Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal.

Review 8. The biology of white adipocyte proliferation.

Review 9. The biophysics and cell biology of lipid droplets.