M Weinstein1, D Ben Bashat2, V Gross-Tsur3, Y Leitner4, I Berger5, R Marom5, R Geva6, S Uliel7, L Ben-Sira8. 1. 1] Functional Brain Center, Wohl Institute for Advanced Imaging, Tel-Aviv Sourasky Medical Center (TASMC), Tel-Aviv, Israel [2] Department of Psychology, Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat-Gan, Israel. 2. 1] Functional Brain Center, Wohl Institute for Advanced Imaging, Tel-Aviv Sourasky Medical Center (TASMC), Tel-Aviv, Israel [2] Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel [3] Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel. 3. Department of Pediatric Neurology, Shaare-Zedek Medical Center, Jerusalem, Israel. 4. 1] Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel [2] Department of Pediatrics, Child Development Center, TASMC, Tel-Aviv, Israel. 5. 1] Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel [2] Department of Neonatology, Lis Maternity Hospital, TASMC, Tel-Aviv, Israel. 6. Department of Psychology, Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat-Gan, Israel. 7. Department of Pediatrics, Child Development Center, TASMC, Tel-Aviv, Israel. 8. 1] Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel [2] Department of Radiology, TASMC, Tel-Aviv, Israel.
Abstract
OBJECTIVE: To compare echogenicity detected using cranial ultrasound (cUS) and diffuse excessive high signal intensity (DEHSI) detected using magnetic resonance imaging (MRI) by identical region-based scoring criteria in preterm infants. To explore the association between these white matter (WM) signal changes with early neurobehavior. STUDY DESIGN: Forty-nine pre-selected premature infants with only echogenicity on a first routine cUS1 underwent MRI and a repeated cUS2 at term equivalent age. Echogenicity and DEHSI were graded in various brain areas and diffusivity values were calculated. Neurobehavior was assessed using the Rapid Neonatal Neurobehavioral Assessment Procedure. RESULT: WM signal changes were significantly higher on cUS1 than cUS2; and higher in MRI than cUS2 in posterior regions. Infants with DEHSI demonstrated reduced tissue integrity. Imaging findings were not correlated with early neurobehavior. CONCLUSION: Echogenicity and DEHSI likely represent the same phenomenon. Reduction of over-interpretation of WM signal changes may help define criteria for the judicious use of imaging in routine follow-up of premature infants.
OBJECTIVE: To compare echogenicity detected using cranial ultrasound (cUS) and diffuse excessive high signal intensity (DEHSI) detected using magnetic resonance imaging (MRI) by identical region-based scoring criteria in preterm infants. To explore the association between these white matter (WM) signal changes with early neurobehavior. STUDY DESIGN: Forty-nine pre-selected premature infants with only echogenicity on a first routine cUS1 underwent MRI and a repeated cUS2 at term equivalent age. Echogenicity and DEHSI were graded in various brain areas and diffusivity values were calculated. Neurobehavior was assessed using the Rapid Neonatal Neurobehavioral Assessment Procedure. RESULT: WM signal changes were significantly higher on cUS1 than cUS2; and higher in MRI than cUS2 in posterior regions. Infants with DEHSI demonstrated reduced tissue integrity. Imaging findings were not correlated with early neurobehavior. CONCLUSION: Echogenicity and DEHSI likely represent the same phenomenon. Reduction of over-interpretation of WM signal changes may help define criteria for the judicious use of imaging in routine follow-up of premature infants.
Authors: E F Maalouf; P J Duggan; M A Rutherford; S J Counsell; A M Fletcher; M Battin; F Cowan; A D Edwards Journal: J Pediatr Date: 1999-09 Impact factor: 4.406
Authors: Lara M Leijser; Francisca T de Bruïne; Sylke J Steggerda; Jeroen van der Grond; Frans J Walther; Gerda van Wezel-Meijler Journal: Early Hum Dev Date: 2009-01-13 Impact factor: 2.079
Authors: Francisca T de Bruïne; Annette A van den Berg-Huysmans; Lara M Leijser; Monique Rijken; Sylke J Steggerda; Jeroen van der Grond; Gerda van Wezel-Meijler Journal: Radiology Date: 2011-10-26 Impact factor: 11.105
Authors: E F Maalouf; P J Duggan; S J Counsell; M A Rutherford; F Cowan; D Azzopardi; A D Edwards Journal: Pediatrics Date: 2001-04 Impact factor: 7.124