| Literature DB >> 24649354 |
Takeshi Kajiwara1, Yoichi Hiasa2, Tomohiro Nishina1, Toshihiko Matsumoto1, Shinichiro Hori1, Seijin Nadano1, Haruo Iguchi1, Satoru Takeji2, Eiji Tsubouchi2, Yoshio Ikeda2, Morikazu Onji2.
Abstract
Positron emission tomography/computed tomography (PET/CT) with 18F-fluoro-2-deoxyglucose (FDG-PET/CT) has become established in cancer imaging, and derived maximum standardized uptake values (SUVmax) add functional information regarding cancer, including esophageal squamous cell carcinoma (ESCC). The aim of the present study was to determine the clinical significance and association of tumor progression using SUVmax derived from PET/CT images in patients with ESCC. In total, 101 patients with ESCC were assessed using FDG-PET/CT and the SUVmax was then compared with the clinical backgrounds and prognoses of the patients. Endoscopic ESCC biopsy specimens were obtained in order to analyze mRNA expression relative to tumor progression. The results showed that values for SUVmax were significantly higher in patients with tumor progression factors, particularly those with lymph node metastasis. Analysis of receiver operating characteristics curves revealed an optimum SUVmax cut-off value of 10.26 for node-positive disease. Patients with SUVmax ≥10.26 had gene alterations with epithelial-mesenchymal transition (EMT) and significantly worse overall survival (P=0.0012). A higher SUVmax in patients with ESCC was associated with lymph node metastasis and a poorer prognosis. Thus, the SUVmax may reflect the potential of EMT in patients with ESCC.Entities:
Keywords: 18F-fluoro-2-deoxyglucose; epithelial-mesenchymal transition; esophageal squamous cell carcinoma; maximum standardized uptake value; positron emission tomography
Year: 2014 PMID： 24649354 PMCID： PMC3917778 DOI： 10.3892/mco.2014.238
Source DB: PubMed Journal: Mol Clin Oncol ISSN： 2049-9450