Literature DB >> 24649038

The emerging role of interleukin-21 in allergic diseases (Review).

Fang Gong1, Qiang Su2, Yu Hong Pan1, Xuan Huang1, Wei Hong Shen1.   

Abstract

Interleukin (IL)-21 is a newly discovered member of the type I cytokine family. Since its discovery in 2000, IL-21 has been the focus of extensive investigation, due to its homology to IL-2, IL-4 and IL-15 and its pleiotropic effects on innate and adaptive immune responses. An increasing amount of experimental evidence supports a role for IL-21 in the pathogenesis of several allergic diseases, such as allergic rhinitis, atopic dermatitis (AD) and atopic asthma. In this review, we aimed to discuss the biological characteristics of IL-21 and summarize the current progress on the role of IL-21 in the regulation of allergic inflammation.

Entities:  

Keywords:  allergic rhinitis; atopic asthma; atopic dermatitis; interleukin-21

Year:  2013        PMID： 24649038      PMCID： PMC3917548          DOI： 10.3892/br.2013.166

Source DB:  PubMed          Journal:  Biomed Rep        ISSN： 2049-9434


  21 in total

1.  IL-21 induces the apoptosis of resting and activated primary B cells.

Authors:  Devangi S Mehta; Andrea L Wurster; Matthew J Whitters; Deborah A Young; Mary Collins; Michael J Grusby
Journal:  J Immunol       Date:  2003-04-15       Impact factor: 5.422

Review 2.  Interleukin-21 in immune and allergic diseases.

Authors:  Massimiliano Sarra; Maria Laura Cupi; Francesco Pallone; Giovanni Monteleone
Journal:  Inflamm Allergy Drug Targets       Date:  2012-08-01

Review 3.  Asthma phenotypes: the evolution from clinical to molecular approaches.

Authors:  Sally E Wenzel
Journal:  Nat Med       Date:  2012-05-04       Impact factor: 53.440

4.  Atopic dermatitis.

Authors:  Thomas Bieber
Journal:  N Engl J Med       Date:  2008-04-03       Impact factor: 91.245

5.  Decrease in circulating Th17 cells correlates with increased levels of CCL17, IgE and eosinophils in atopic dermatitis.

Authors:  Sayaka Hayashida; Hiroshi Uchi; Yoichi Moroi; Masutaka Furue
Journal:  J Dermatol Sci       Date:  2010-11-03       Impact factor: 4.563

6.  IL-21 administration into the nostril alleviates murine allergic rhinitis.

Authors:  Yayoi Hiromura; Tsunao Kishida; Hiroshi Nakano; Takemitsu Hama; Jiro Imanishi; Yasuo Hisa; Osam Mazda
Journal:  J Immunol       Date:  2007-11-15       Impact factor: 5.422

7.  Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis.

Authors:  Roberta Caruso; Elisabetta Botti; Massimiliano Sarra; Maria Esposito; Carmine Stolfi; Laura Diluvio; Maria Laura Giustizieri; Valentina Pacciani; Annamaria Mazzotta; Elena Campione; Thomas T Macdonald; Sergio Chimenti; Francesco Pallone; Antonio Costanzo; Giovanni Monteleone
Journal:  Nat Med       Date:  2009-08-16       Impact factor: 53.440

Review 8.  The development of allergic inflammation.

Authors:  Stephen J Galli; Mindy Tsai; Adrian M Piliponsky
Journal:  Nature       Date:  2008-07-24       Impact factor: 49.962

9.  Allergic rhinitis.

Authors:  Peter Small; Harold Kim
Journal:  Allergy Asthma Clin Immunol       Date:  2011-11-10       Impact factor: 3.406

10.  IL-21-induced Bepsilon cell apoptosis mediated by natural killer T cells suppresses IgE responses.

Authors:  Michishige Harada; Kumiko Magara-Koyanagi; Hiroshi Watarai; Yuko Nagata; Yasuyuki Ishii; Satoshi Kojo; Shigetoshi Horiguchi; Yoshitaka Okamoto; Toshinori Nakayama; Nobutaka Suzuki; Wen-Chen Yeh; Shizuo Akira; Hiroshi Kitamura; Osamu Ohara; Ken-ichiro Seino; Masaru Taniguchi
Journal:  J Exp Med       Date:  2006-12-18       Impact factor: 14.307
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  4 in total

1.  Interleukin-21 polymorphism affects gene expression and is associated with risk of ischemic stroke.

Authors:  Guanggang Li; Ruxiang Xu; Yinghua Cao; Xiaodong Xie; Zhendong Zheng
Journal:  Inflammation       Date:  2014-12       Impact factor: 4.092

2.  Machine learning reveals distinct gene signature profiles in lesional and nonlesional regions of inflammatory skin diseases.

Authors:  Brittany A Martínez; Sneha Shrotri; Kathryn M Kingsmore; Prathyusha Bachali; Amrie C Grammer; Peter E Lipsky
Journal:  Sci Adv       Date:  2022-04-29       Impact factor: 14.957

3.  Th-17 regulatory cytokines inhibit corticosteroid induced airway structural cells apoptosis.

Authors:  Rabih Halwani; Asma Sultana; Roua Al-Kufaidy; Amer Jamhawi; Alejandro Vazquez-Tello; Saleh Al-Muhsen
Journal:  Respir Res       Date:  2016-01-16

4.  Serum Ghrelin Levels in Saudi Obese Asthmatic School-Children-Correlation with Interleukin-4, Interleukin-5, and Interleukin-21.

Authors:  Mohammed Saeed Al-Ayed; Khaled Sadeq Al-Shaibari; Dhafer Alshehri; Mohammed Jamaan Alzahrani; Iman Nasser; Hamdan Saad Alaamri; Wed Ahmad Alaseeri; Ahmed A Mahfouz; Saeed Ali Alsareii; Ahmed Morad Asaad; Aamir Magzoub; Mohammed Ansar Qureshi; Ehab Elagab; Elhashimi Eltayb Hassan; Mohammed Helmy Faris Shalayel
Journal:  Int J Environ Res Public Health       Date:  2020-03-04       Impact factor: 3.390
  4 in total

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