Literature DB >> 19684581

Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis.

Roberta Caruso1, Elisabetta Botti, Massimiliano Sarra, Maria Esposito, Carmine Stolfi, Laura Diluvio, Maria Laura Giustizieri, Valentina Pacciani, Annamaria Mazzotta, Elena Campione, Thomas T Macdonald, Sergio Chimenti, Francesco Pallone, Antonio Costanzo, Giovanni Monteleone.   

Abstract

T cells are crucial mediators of the skin damage in psoriasis. We here show that interleukin-21 (IL-21), a T cell-derived cytokine, is highly expressed in the skin of individuals with psoriasis, stimulates human keratinocytes to proliferate and causes epidermal hyperplasia when injected intradermally into mice. In the human psoriasis xenograft mouse model, blockade of IL-21 activity resolves inflammation and reduces keratinocyte proliferation. Blocking IL-21 may represent a new therapeutic strategy in psoriasis.

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Year:  2009        PMID： 19684581     DOI： 10.1038/nm.1995

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  9 in total

1.  Extracellular regulated kinase and c-Jun N-terminal kinase are activated in psoriatic involved epidermis.

Authors:  Hidetoshi Takahashi; Masaki Ibe; Satoshi Nakamura; Akemi Ishida-Yamamoto; Yoshio Hashimoto; Hajime Iizuka
Journal:  J Dermatol Sci       Date:  2002-11       Impact factor: 4.563

2.  Dermal injection of immunocytes induces psoriasis.

Authors:  T Wrone-Smith; B J Nickoloff
Journal:  J Clin Invest       Date:  1996-10-15       Impact factor: 14.808

3.  Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis.

Authors:  Yan Zheng; Dimitry M Danilenko; Patricia Valdez; Ian Kasman; Jeffrey Eastham-Anderson; Jianfeng Wu; Wenjun Ouyang
Journal:  Nature       Date:  2006-12-24       Impact factor: 49.962

Review 4.  Pathogenesis and therapy of psoriasis.

Authors:  Michelle A Lowes; Anne M Bowcock; James G Krueger
Journal:  Nature       Date:  2007-02-22       Impact factor: 49.962

5.  Autocrine regulation of IL-21 production in human T lymphocytes.

Authors:  Flavio Caprioli; Massimiliano Sarra; Roberta Caruso; Carmine Stolfi; Daniele Fina; Giuseppe Sica; Thomas T MacDonald; Francesco Pallone; Giovanni Monteleone
Journal:  J Immunol       Date:  2008-02-01       Impact factor: 5.422

6.  IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation.

Authors:  Hak-Ling Ma; Spencer Liang; Jing Li; Lee Napierata; Tom Brown; Stephen Benoit; Mayra Senices; Davinder Gill; Kyriaki Dunussi-Joannopoulos; Mary Collins; Cheryl Nickerson-Nutter; Lynette A Fouser; Deborah A Young
Journal:  J Clin Invest       Date:  2008-02       Impact factor: 14.808

Review 7.  Interleukin-21: a critical regulator of the balance between effector and regulatory T-cell responses.

Authors:  Giovanni Monteleone; Francesco Pallone; Thomas T MacDonald
Journal:  Trends Immunol       Date:  2008-04-25       Impact factor: 16.687

8.  Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions.

Authors:  Robin M Hobbs; Violeta Silva-Vargas; Richard Groves; Fiona M Watt
Journal:  J Invest Dermatol       Date:  2004-09       Impact factor: 8.551

9.  A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.

Authors:  Ying Liu; Cynthia Helms; Wilson Liao; Lisa C Zaba; Shenghui Duan; Jennifer Gardner; Carol Wise; Andrew Miner; M J Malloy; Clive R Pullinger; John P Kane; Scott Saccone; Jane Worthington; Ian Bruce; Pui-Yan Kwok; Alan Menter; James Krueger; Anne Barton; Nancy L Saccone; Anne M Bowcock
Journal:  PLoS Genet       Date:  2008-03-28       Impact factor: 5.917
  9 in total
  64 in total

1.  IL-23 and IL-17A, but not IL-12 and IL-22, are required for optimal skin host defense against Candida albicans.

Authors:  Shinji Kagami; Heather L Rizzo; Stephen E Kurtz; Lloyd S Miller; Andrew Blauvelt
Journal:  J Immunol       Date:  2010-10-04       Impact factor: 5.422

Review 2.  Biologic therapies in the treatment of psoriasis: a comprehensive evidence-based basic science and clinical review and a practical guide to tuberculosis monitoring.

Authors:  Raja K Sivamani; Heidi Goodarzi; Miki Shirakawa Garcia; Siba P Raychaudhuri; Lisa N Wehrli; Yoko Ono; Emanual Maverakis
Journal:  Clin Rev Allergy Immunol       Date:  2013-04       Impact factor: 8.667

Review 3.  Psoriasis: what we have learned from mouse models.

Authors:  Erwin F Wagner; Helia B Schonthaler; Juan Guinea-Viniegra; Erwin Tschachler
Journal:  Nat Rev Rheumatol       Date:  2010-09-28       Impact factor: 20.543

Review 4.  IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease.

Authors:  Jarod Zepp; Ling Wu; Xiaoxia Li
Journal:  Trends Immunol       Date:  2011-04-12       Impact factor: 16.687

Review 5.  The role of secukinumab in the treatment of psoriatic arthritis and ankylosing spondylitis.

Authors:  Leticia Garcia-Montoya; Helena Marzo-Ortega
Journal:  Ther Adv Musculoskelet Dis       Date:  2018-09-06       Impact factor: 5.346

Review 6.  Interleukin-21: a double-edged sword with therapeutic potential.

Authors:  Rosanne Spolski; Warren J Leonard
Journal:  Nat Rev Drug Discov       Date:  2014-04-22       Impact factor: 84.694

7.  Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation.

Authors:  Yihua Cai; Xiaoyan Shen; Chuanlin Ding; Chunjian Qi; Kejia Li; Xia Li; Venkatakrishna R Jala; Huang-ge Zhang; Tian Wang; Jie Zheng; Jun Yan
Journal:  Immunity       Date:  2011-10-06       Impact factor: 31.745

8.  The differential regulation of human ACT1 isoforms by Hsp90 in IL-17 signaling.

Authors:  Ling Wu; Chenhui Wang; Bertrand Boisson; Saurav Misra; Patricia Rayman; James H Finke; Anne Puel; Jean-Laurent Casanova; Xiaoxia Li
Journal:  J Immunol       Date:  2014-07-14       Impact factor: 5.422

9.  Biological therapy of psoriasis.

Authors:  Raja K Sivamani; Genevieve Correa; Yoko Ono; Michael P Bowen; Siba P Raychaudhuri; Emanual Maverakis
Journal:  Indian J Dermatol       Date:  2010 Apr-Jun       Impact factor: 1.494

10.  Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin.

Authors:  Alexis Dumortier; André-Dante Durham; Matteo Di Piazza; Sophie Vauclair; Ute Koch; Gisèle Ferrand; Isabel Ferrero; Shadmehr Demehri; Lynda Li Song; Andrew G Farr; Warren J Leonard; Raphael Kopan; Lucio Miele; Daniel Hohl; Daniela Finke; Freddy Radtke
Journal:  PLoS One       Date:  2010-02-18       Impact factor: 3.240
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