Literature DB >> 2464831

Effects of calcitonin gene-related peptide on synaptic acetylcholine receptor-channels in rat muscle fibres.

F Eusebi1, D Farini, F Grassi, L Monaco, F Ruzzier.   

Abstract

Cultured myotubes and freshly dissociated muscle fibres from adult rats were exposed to calcitonin gene-related peptide (CGRP) and studied by patch-clamp recording during the peptide-induced maximal accumulation of cellular cyclic AMP (cAMP). Acetylcholine receptor- (AChR-) channel properties in myotubes were not modified by the presence of CGRP (10(-7) M). The peptide, applied to the non-patched membrane, significantly increased the variance of the AChR-channel amplitude distribution at the synaptic region of muscle fibres, and three classes of AChR-channels were resolved immediately after peptide application. AChR-channels at extrasynaptic regions of fibres from denervated muscles were unaffected by CGRP. It is suggested that CGRP may regulate the synaptic AChR-channel conductance through second messenger systems.

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Year:  1988        PMID： 2464831     DOI： 10.1098/rspb.1988.0052

Source DB:  PubMed          Journal:  Proc R Soc Lond B Biol Sci        ISSN： 0950-1193


  7 in total

1.  Modulation of voltage-activated channels by calcitonin gene-related peptide in cultured rat neurones.

Authors:  C Zona; D Farini; E Palma; F Eusebi
Journal:  J Physiol       Date:  1991-02       Impact factor: 5.182

2.  Interleukin-2 lengthens extrajunctional acetylcholine receptor channel open time in mammalian muscle cells.

Authors:  P Lorenzon; F Ruzzier; C G Caratsch; A Giovannelli; F Velotti; A Santoni; F Eusebi
Journal:  Pflugers Arch       Date:  1991-10       Impact factor: 3.657

3.  Calcitonin gene-related peptide rapidly downregulates nicotinic receptor function and slowly raises intracellular Ca2+ in rat chromaffin cells in vitro.

Authors:  R Giniatullin; S Di Angelantonio; C Marchetti; E Sokolova; L Khiroug; A Nistri
Journal:  J Neurosci       Date:  1999-04-15       Impact factor: 6.167

4.  Two forms of acetylcholine receptor gamma subunit in mouse muscle.

Authors:  A M Mileo; L Monaco; E Palma; F Grassi; R Miledi; F Eusebi
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-28       Impact factor: 11.205

Review 5.  Modulation of neuronal nicotinic receptor function by the neuropeptides CGRP and substance P on autonomic nerve cells.

Authors:  Silvia Di Angelantonio; Rashid Giniatullin; Valeria Costa; Elena Sokolova; Andrea Nistri
Journal:  Br J Pharmacol       Date:  2003-07       Impact factor: 8.739

6.  Regulation of muscle acetylcholine receptor-channel function by interferon.

Authors:  F Eusebi; D Farini; F Grassi; A Santoni
Journal:  Pflugers Arch       Date:  1989-11       Impact factor: 3.657

7.  Regulation of acetylcholine receptor function by the phorbol ester TPA in rat skeletal muscle.

Authors:  C G Caratsch; F Knoflach; F Grassi; F Eusebi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-07       Impact factor: 3.000
  7 in total

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