Literature DB >> 2480577

Regulation of muscle acetylcholine receptor-channel function by interferon.

F Eusebi1, D Farini, F Grassi, A Santoni.   

Abstract

The effect of the antiviral agent interferon (IFN) on the function of the nicotinic acetylcholine receptor (AChR) channel, has been investigated in both mammalian cultured myotubes and adult fibres, using the single channel recording patch-clamp technique. Shortened AChR-channel lifetime, and occasionally reduced channel conductance and slowed opening frequency were seen with fibroblast IFN (IFN-beta) in the mouse myotubes, and with IFN-beta and leucocytes IFN (IFN-alpha), in the rat muscle fibres. These effects paralleled an increase in the cytosolic level of cAMP. This suggests that IFN exerts a regulatory action on AChR function. A similar regulatory action on other receptor may be responsible for some of the neurological side effects observed in patients treated with IFN.

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Year:  1989        PMID： 2480577     DOI： 10.1007/bf00370585

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  28 in total

1.  An interferon-induced increase in cyclic AMP levels precedes the establishment of the antiviral state.

Authors:  M F Meldolesi; R M Friedman; L D Kohn
Journal:  Biochem Biophys Res Commun       Date:  1977-11-07       Impact factor: 3.575

2.  A possible involvement of cyclic AMP in the expression of desensitization of the nicotinic acetylcholine receptor. A study with forskolin and its analogs.

Authors:  E X Albuquerque; S S Deshpande; Y Aracava; M Alkondon; J W Daly
Journal:  FEBS Lett       Date:  1986-04-07       Impact factor: 4.124

3.  Acetylcholine receptor channel properties in rat myotubes exposed to forskolin.

Authors:  F Grassi; L Monaco; F Eusebi
Journal:  Biochem Biophys Res Commun       Date:  1987-09-30       Impact factor: 3.575

4.  Genetic analysis of the role of cAMP in mediating effects of interferon.

Authors:  J Schneck; B Rager-Zisman; O M Rosen; B R Bloom
Journal:  Proc Natl Acad Sci U S A       Date:  1982-03       Impact factor: 11.205

5.  Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

Authors:  O P Hamill; A Marty; E Neher; B Sakmann; F J Sigworth
Journal:  Pflugers Arch       Date:  1981-08       Impact factor: 3.657

6.  Effect of interferon on concentrations of cyclic nucleotides in cultured cells.

Authors:  M G Tovey; C Rochette-Egly; M Castagna
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

7.  Acetylcholine may regulate its own nicotinic receptor-channel through the C-kinase system.

Authors:  F Eusebi; F Grassi; C Nervi; C Caporale; S Adamo; B M Zani; M Molinaro
Journal:  Proc R Soc Lond B Biol Sci       Date:  1987-04-22

8.  Acetylcholine regulation of nicotinic receptor channels through a putative G protein in chick myotubes.

Authors:  F Eusebi; F Grassi; M Molinaro; B M Zani
Journal:  J Physiol       Date:  1987-12       Impact factor: 5.182

9.  Cyclic AMP regulates the life time of acetylcholine-activated channels in cultured myotubes.

Authors:  B M Zani; F Grassi; M Molinaro; L Monaco; F Eusebi
Journal:  Biochem Biophys Res Commun       Date:  1986-10-15       Impact factor: 3.575

10.  Electrophysiological properties of the membrane and acetylcholine receptor in developing rat and chick myotubes.

Authors:  A K Ritchie; D M Fambrough
Journal:  J Gen Physiol       Date:  1975-09       Impact factor: 4.086
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  1 in total

1.  Interleukin-2 lengthens extrajunctional acetylcholine receptor channel open time in mammalian muscle cells.

Authors:  P Lorenzon; F Ruzzier; C G Caratsch; A Giovannelli; F Velotti; A Santoni; F Eusebi
Journal:  Pflugers Arch       Date:  1991-10       Impact factor: 3.657
  1 in total

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