OBJECTIVES: To evaluate whether daily administration of Lactobacillus reuteri DSM 17938 reduces the frequency and duration of diarrheal episodes and other health outcomes in day school children in Mexico. METHODS:Healthy children (born at term, aged 6-36 months) attending day care centers were enrolled in this randomized, double-blind, placebo-controlled trial. They received L reuteri DSM 17938 (dose 10(8) colony-forming unit; n = 168) or identical placebo (n = 168) by mouth, daily for 3 months, after which they were followed-up after a further 3 months without supplementation. RESULTS: Data from all children were included in the final analysis. L reuteri DSM 17938 significantly reduced the frequency and duration of episodes of diarrhea and respiratory tract infection at both 3 and 6 months (P < .05). Additionally, the number of doctor visits, antibiotic use, absenteeism from day school and parental absenteeism from work were significantly reduced in the L reuteri group (P < .05). A cost-benefit analysis revealed significant reductions in costs in the L reuteri-treated children. No adverse events related to the study product were reported. CONCLUSIONS: In healthy children attending day care centers, daily administration of L reuteri DSM 17938 had a significant effect in reducing episodes and duration of diarrhea and respiratory tract infection, with consequent cost savings for the community.
RCT Entities:
OBJECTIVES: To evaluate whether daily administration of Lactobacillus reuteri DSM 17938 reduces the frequency and duration of diarrheal episodes and other health outcomes in day school children in Mexico. METHODS: Healthy children (born at term, aged 6-36 months) attending day care centers were enrolled in this randomized, double-blind, placebo-controlled trial. They received L reuteri DSM 17938 (dose 10(8) colony-forming unit; n = 168) or identical placebo (n = 168) by mouth, daily for 3 months, after which they were followed-up after a further 3 months without supplementation. RESULTS: Data from all children were included in the final analysis. L reuteri DSM 17938 significantly reduced the frequency and duration of episodes of diarrhea and respiratory tract infection at both 3 and 6 months (P < .05). Additionally, the number of doctor visits, antibiotic use, absenteeism from day school and parental absenteeism from work were significantly reduced in the L reuteri group (P < .05). A cost-benefit analysis revealed significant reductions in costs in the L reuteri-treated children. No adverse events related to the study product were reported. CONCLUSIONS: In healthy children attending day care centers, daily administration of L reuteri DSM 17938 had a significant effect in reducing episodes and duration of diarrhea and respiratory tract infection, with consequent cost savings for the community.
Authors: Jacob K Olson; Jason B Navarro; Jacob M Allen; Christopher J McCulloh; Lauren Mashburn-Warren; Yijie Wang; Vanessa A Varaljay; Michael T Bailey; Steven D Goodman; Gail E Besner Journal: Am J Physiol Gastrointest Liver Physiol Date: 2018-05-31 Impact factor: 4.052
Authors: Sylvia Becker-Dreps; Imane Allali; Andrea Monteagudo; Samuel Vilchez; Michael G Hudgens; Elizabeth T Rogawski; Ian M Carroll; Luis Enrique Zambrana; Felix Espinoza; M Andrea Azcarate-Peril Journal: Am J Trop Med Hyg Date: 2015-09-08 Impact factor: 2.345
Authors: Anna M Scott; Justin Clark; Blair Julien; Farhana Islam; Kristian Roos; Keith Grimwood; Paul Little; Chris B Del Mar Journal: Cochrane Database Syst Rev Date: 2019-06-18
Authors: Amanda L Thompson; Andrea Monteagudo-Mera; Maria B Cadenas; Michelle L Lampl; M A Azcarate-Peril Journal: Front Cell Infect Microbiol Date: 2015-02-05 Impact factor: 5.293