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Literature DB >> 24636338

Involvement of deleted chromosome 5 in complex chromosomal aberrations in newly diagnosed myelodysplastic syndromes (MDS) is correlated with extremely adverse prognosis.

Zuzana Zemanova¹, Kyra Michalova², Halka Buryova³, Jana Brezinova⁴, Karla Kostylkova³, Dagmar Bystricka³, Milena Novakova³, Iveta Sarova⁴, Silvia Izakova³, Libuse Lizcova³, Sarka Ransdorfova⁴, Zdenek Krejcik⁴, Michaela Dostalova Merkerova⁴, Alena Dohnalova⁵, Magda Siskova⁶, Anna Jonasova⁶, Radana Neuwirtova⁶, Jaroslav Cermak⁴.

Abstract

MDS with complex chromosomal aberrations (CCA) are characterized by short survival and a high rate of transformation to AML. A comprehensive genome-wide analysis of bone-marrow cells of 157 adults with newly diagnosed MDS and CCA revealed a large spectrum of nonrandom genomic changes related to the advanced stages of MDS. Chromosome shattering, probably resulting from chromothripsis, was found in 47% of patients. Deleted chromosome 5 was unstable and often involved in different types of cryptic unbalanced rearrangements. No true monosomy 5 was observed. Patients with CCA involving deleted chromosome 5 had an extremely poor prognosis (median overall survival, 2 months).

Entities: Disease Species

Keywords: Chromothripsis; Complex chromosomal aberrations; Deletion 5q; Genome instability; Myelodysplastic syndromes

Mesh：

Year: 2014 PMID： 24636338 DOI： 10.1016/j.leukres.2014.01.012

Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156

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Cited

9 in total

1. Chromothripsis: Basis of a Concurrent Unusual Association between Myelodysplastic Syndrome and Primary Ciliary Dyskinesia.

Authors: Abhinav Agrawal; Anar Modi; Sayee Sundar Alagusundaramoorthy; Wael Ghali
Journal: Case Rep Hematol Date: 2014-09-01

2. Identify latent chromosomal aberrations relevant to myelodysplastic syndromes.

Authors: Qibin Song; Yuxin Chu; Yi Yao; Min Peng; Weihong Yang; Xiaoqing Li; Shiang Huang
Journal: Sci Rep Date: 2017-09-04 Impact factor: 4.379

3. Chromothripsis Is a Recurrent Genomic Abnormality in High-Risk Myelodysplastic Syndromes.

Authors: María Abáigar; Cristina Robledo; Rocío Benito; Fernando Ramos; María Díez-Campelo; Lourdes Hermosín; Javier Sánchez-Del-Real; Jose M Alonso; Rebeca Cuello; Marta Megido; Juan N Rodríguez; Guillermo Martín-Núñez; Carlos Aguilar; Manuel Vargas; Ana A Martín; Juan L García; Alexander Kohlmann; M Consuelo Del Cañizo; Jesús M Hernández-Rivas
Journal: PLoS One Date: 2016-10-14 Impact factor: 3.240

4. Progression in patients with low- and intermediate-1-risk del(5q) myelodysplastic syndromes is predicted by a limited subset of mutations.

Authors: Christian Scharenberg; Valentina Giai; Andrea Pellagatti; Leonie Saft; Marios Dimitriou; Monika Jansson; Martin Jädersten; Alf Grandien; Iyadh Douagi; Donna S Neuberg; Katarina LeBlanc; Jacqueline Boultwood; Mohsen Karimi; Sten Eirik W Jacobsen; Petter S Woll; Eva Hellström-Lindberg
Journal: Haematologica Date: 2016-11-24 Impact factor: 9.941

8. Myelodysplasia-Related Features of Acute Myeloid Leukemia Evolving From Philadelphia-Negative Myeloproliferative Neoplasms.

Authors: Jae Ryuk Kim; Young Uk Cho; Mi Hyun Bae; Bohyun Kim; Seongsoo Jang; Eul Ju Seo; Hyun Sook Chi; Chan Jeoung Park
Journal: Ann Lab Med Date: 2016-07 Impact factor: 3.464

Review 9. Techniques for detecting chromosomal aberrations in myelodysplastic syndromes.

Authors: Qibin Song; Min Peng; Yuxin Chu; Shiang Huang
Journal: Oncotarget Date: 2017-05-09