Rebecca E Pratt1, Rae-Ellen Kavey2, Donna Quinzi2. 1. University of Rochester Medical Center, 601 Elmwood Avenue, Box 631, Rochester, NY 14642. Electronic address: rprattmd@gmail.com. 2. University of Rochester Medical Center, 601 Elmwood Avenue, Box 631, Rochester, NY 14642.
Abstract
BACKGROUND: Combined dyslipidemia (elevated triglyceride [TG] ± non-high-density lipoprotein cholesterol [non-HDL-C] ± total cholesterol [TC] ± low-density lipoprotein cholesterol [LDL-C] ± reduced high-density lipoprotein cholesterol [HDL-C]) is seen in >40% of obese children. Primary recommended treatment is weight loss with limited reports of any other approach. OBJECTIVE: In children with combined dyslipidemia, evaluate the response to a clinical protocol focused on diet composition change and increased activity with no direct weight loss approach. METHODS: Retrospective review of lipid profile and growth parameter changes in patients 6 to 18 years of age with diagnosis of combined dyslipidemia seen between December 31, 2009, and December 31, 2011, managed with this protocol through 2 follow-up visits. Combined dyslipidemia diagnosed when ≥2 lipid values exceed the upper limit of normal for TC, TG, non-HDL-C, or LDL-C ± HDL-C below the lower limit of normal. RESULTS: Fifty-three patients were identified, 55% male, 92% obese, mean age 12.1 ± 3.4 years with mean follow-up 9.2 months. Lipid parameters (mean ± SD, mg/dL) improved significantly (P < .001): TC 209 ± 39 to 181 ± 32; TG 255 ± 119 to168 ± 99; non-HDL-C 167 ± 35 to 138 ± 30 and LDL-C 121 ± 43 to 106 ± 30. HDL-C was unchanged. Body mass index decreased in 58% and mean body mass index decreased 0.67 kg/m(2) (P < .05). CONCLUSIONS: Focused lifestyle changes significantly improved combined dyslipidemia in obese children. With no direct weight loss approach, body mass index decreased in 58%.
BACKGROUND: Combined dyslipidemia (elevated triglyceride [TG] ± non-high-density lipoprotein cholesterol [non-HDL-C] ± total cholesterol [TC] ± low-density lipoprotein cholesterol [LDL-C] ± reduced high-density lipoprotein cholesterol [HDL-C]) is seen in >40% of obesechildren. Primary recommended treatment is weight loss with limited reports of any other approach. OBJECTIVE: In children with combined dyslipidemia, evaluate the response to a clinical protocol focused on diet composition change and increased activity with no direct weight loss approach. METHODS: Retrospective review of lipid profile and growth parameter changes in patients 6 to 18 years of age with diagnosis of combined dyslipidemia seen between December 31, 2009, and December 31, 2011, managed with this protocol through 2 follow-up visits. Combined dyslipidemia diagnosed when ≥2 lipid values exceed the upper limit of normal for TC, TG, non-HDL-C, or LDL-C ± HDL-C below the lower limit of normal. RESULTS: Fifty-three patients were identified, 55% male, 92% obese, mean age 12.1 ± 3.4 years with mean follow-up 9.2 months. Lipid parameters (mean ± SD, mg/dL) improved significantly (P < .001): TC 209 ± 39 to 181 ± 32; TG 255 ± 119 to168 ± 99; non-HDL-C 167 ± 35 to 138 ± 30 and LDL-C 121 ± 43 to 106 ± 30. HDL-C was unchanged. Body mass index decreased in 58% and mean body mass index decreased 0.67 kg/m(2) (P < .05). CONCLUSIONS: Focused lifestyle changes significantly improved combined dyslipidemia in obesechildren. With no direct weight loss approach, body mass index decreased in 58%.
Authors: Guanghong Jia; Annayya R Aroor; Luis A Martinez-Lemus; James R Sowers Journal: Am J Physiol Regul Integr Comp Physiol Date: 2014-09-24 Impact factor: 3.619
Authors: Justin P Zachariah; James Chan; Michael M Mendelson; Todd Regh; Suzanne Griggs; Philip K Johnson; Nirav Desai; Mathew Gillman; Dionne Graham; Sarah D de Ferranti Journal: J Am Coll Cardiol Date: 2016-11-08 Impact factor: 24.094