OBJECTIVES: To assess the usefulness of the Montreal Cognitive Assessment (MoCA) total score (MoCA-TS) and Memory Index Score (MoCA-MIS) in predicting conversion to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI). DESIGN: Retrospective chart review. SETTING: Community-based memory clinic. PARTICIPANTS: Individuals meeting Petersen's MCI criteria (N = 165). MEASUREMENTS: Baseline MoCA scores at MCI diagnosis were collected from charts of eligible individuals with MCI, and MoCA-TS, MoCA-MIS, and a cognitive domain index score were calculated to assess their prognostic value in predicting conversion to AD. RESULTS: One hundred fourteen participants progressed to AD (MCI-AD), and 51 did not (nonconverters; MCI-NC); 90.5% of participants with MCI with a MoCA-TS less than 20/30 and a MoCA-MIS less than 7/15 at baseline converted to AD within the average follow-up period of 18 months, compared with 52.7% of participants with MCI above the cutoffs on both scores. Individuals with multiple-domain amnestic MCI had the highest AD conversion rates (73.9%). CONCLUSION: Identifying individuals with MCI at high risk of conversion to AD is important clinically and for selecting appropriate subjects for therapeutic trials. Individuals with MCI with a low MoCA-TS and a low newly devised memory index score (MoCA-MIS) are at greater risk of short-term conversion to AD.
OBJECTIVES: To assess the usefulness of the Montreal Cognitive Assessment (MoCA) total score (MoCA-TS) and Memory Index Score (MoCA-MIS) in predicting conversion to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI). DESIGN: Retrospective chart review. SETTING: Community-based memory clinic. PARTICIPANTS: Individuals meeting Petersen's MCI criteria (N = 165). MEASUREMENTS: Baseline MoCA scores at MCI diagnosis were collected from charts of eligible individuals with MCI, and MoCA-TS, MoCA-MIS, and a cognitive domain index score were calculated to assess their prognostic value in predicting conversion to AD. RESULTS: One hundred fourteen participants progressed to AD (MCI-AD), and 51 did not (nonconverters; MCI-NC); 90.5% of participants with MCI with a MoCA-TS less than 20/30 and a MoCA-MIS less than 7/15 at baseline converted to AD within the average follow-up period of 18 months, compared with 52.7% of participants with MCI above the cutoffs on both scores. Individuals with multiple-domain amnestic MCI had the highest AD conversion rates (73.9%). CONCLUSION: Identifying individuals with MCI at high risk of conversion to AD is important clinically and for selecting appropriate subjects for therapeutic trials. Individuals with MCI with a low MoCA-TS and a low newly devised memory index score (MoCA-MIS) are at greater risk of short-term conversion to AD.
Authors: Joel C Mitchell; Malcolm B Dick; Amanda E Wood; Andre M Tapp; Raphael Ziegler Journal: Alzheimer Dis Assoc Disord Date: 2015 Jul-Sep Impact factor: 2.703
Authors: Tammy T Hshieh; Wooram F Jung; Laura J Grande; Jiaying Chen; Richard M Stone; Robert J Soiffer; Jane A Driver; Gregory A Abel Journal: JAMA Oncol Date: 2018-05-01 Impact factor: 31.777
Authors: Nicole Reams; James T Eckner; Andrea A Almeida; Andrea L Aagesen; Bruno Giordani; Hank Paulson; Matthew T Lorincz; Jeffrey S Kutcher Journal: JAMA Neurol Date: 2016-06-01 Impact factor: 18.302