Thomas Hauser1, Marco Essig2, Alexandra Jensen3, Frederik B Laun4, Marc Münter5, Klaus H Maier-Hein6, Bram Stieltjes7. 1. Department of Radiology (E010), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Nuclear Medicine, Klinikum Augsburg, Augsburg, Germany. Electronic address: Thomas.Hauser@klinikum-augsburg.de. 2. Department of Radiology, University of Manitoba, Winnipeg, Canada. 3. Department of Radiation Therapy, Ruprecht-Karls University, Heidelberg, Germany. 4. Quantitative imaging based disease characterization (E011), German Cancer Research Center (DKFZ), Heidelberg, Germany; Department of Medical Physics in Radiology (E020), German Cancer Research Center (DKFZ), Heidelberg, Germany. 5. Department of Radiation Therapy, Ruprecht-Karls University, Heidelberg, Germany; Department of Radiation Therapy, Katharinenhospital, Stuttgart, Germany. 6. Quantitative imaging based disease characterization (E011), German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Medical and Biological Informatics, German Cancer Research Center (DKFZ), Heidelberg, Germany. 7. Quantitative imaging based disease characterization (E011), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Abstract
PURPOSE: To obtain diffusion and microperfusion measures in lymph node metastases of head and neck squamous cell carcinomas (HNSCC) using intravoxel incoherent motion (IVIM) imaging. The obtained IVIM parameters were used to characterize lymph nodes in the staging phase and longitudinal follow-up was performed to evaluate the potential predictive value of these parameters considering therapy response. METHODS: Fifteen patients with lymph node metastases of histologically confirmed locally advanced HNSCC were examined using diffusion weighted imaging (DWI) before a nonsurgical organ preserving therapy. DWI imaging was performed at 3T using eight different b-values ranging from 0 to 800s/mm(2). Using the IVIM-approach, the perfusion fraction f and the diffusion coefficient D were extracted using a biexponential fit. A follow-up period of 13.5 months was available for all patients. One patient with a macroscopically necrotic lymph node was excluded from analyses. A region of interest (ROI)-analysis was performed in all patients. RESULTS: Locoregional failure (LRF) was present in 3 of 15 patients within 13.5 months follow-up. The initial f-value was significantly higher (p=0.01) in patients with LRF (14.5±0.6% vs. 7.7±2.6%) compared to patients with locoregional control (LRC). The initial diffusion coefficient D did not differ significantly (p=0.30) between the two groups (0.97±0.15×10(-3)mm(2)/s vs. 0.88±0.13×10(-3)mm(2)/s). CONCLUSIONS: Our results indicate that a high initial perfusion fraction f in lymph nodes may predict poor treatment response in patients with HNSCC due to locoregional failure.
PURPOSE: To obtain diffusion and microperfusion measures in lymph node metastases of head and neck squamous cell carcinomas (HNSCC) using intravoxel incoherent motion (IVIM) imaging. The obtained IVIM parameters were used to characterize lymph nodes in the staging phase and longitudinal follow-up was performed to evaluate the potential predictive value of these parameters considering therapy response. METHODS: Fifteen patients with lymph node metastases of histologically confirmed locally advanced HNSCC were examined using diffusion weighted imaging (DWI) before a nonsurgical organ preserving therapy. DWI imaging was performed at 3T using eight different b-values ranging from 0 to 800s/mm(2). Using the IVIM-approach, the perfusion fraction f and the diffusion coefficient D were extracted using a biexponential fit. A follow-up period of 13.5 months was available for all patients. One patient with a macroscopically necrotic lymph node was excluded from analyses. A region of interest (ROI)-analysis was performed in all patients. RESULTS:Locoregional failure (LRF) was present in 3 of 15 patients within 13.5 months follow-up. The initial f-value was significantly higher (p=0.01) in patients with LRF (14.5±0.6% vs. 7.7±2.6%) compared to patients with locoregional control (LRC). The initial diffusion coefficient D did not differ significantly (p=0.30) between the two groups (0.97±0.15×10(-3)mm(2)/s vs. 0.88±0.13×10(-3)mm(2)/s). CONCLUSIONS: Our results indicate that a high initial perfusion fraction f in lymph nodes may predict poor treatment response in patients with HNSCC due to locoregional failure.
Authors: Z Xiao; Z Tang; J Qiang; S Wang; W Qian; Y Zhong; R Wang; J Wang; L Wu; W Tang; Z Zhang Journal: AJNR Am J Neuroradiol Date: 2018-01-25 Impact factor: 3.825
Authors: Yao Ding; John D Hazle; Abdallah S R Mohamed; Steven J Frank; Brian P Hobbs; Rivka R Colen; G Brandon Gunn; Jihong Wang; Jayashree Kalpathy-Cramer; Adam S Garden; Stephen Y Lai; David I Rosenthal; Clifton D Fuller Journal: NMR Biomed Date: 2015-10-09 Impact factor: 4.044