Alaa Alhadad1, Michael Akesson1, Leena Lehti2, Peter Leander3, Gunnar Sterner4, Per Akeson1, Johan Wassélius5. 1. Department of Clinical Sciences Malmö, Lund University, Sweden. 2. Department of Clinical Sciences Malmö, Lund University, Sweden; Vascular Center, Skåne University Hospital, S-20502 Malmö 3. Department of Clinical Sciences Malmö, Lund University, Sweden; Department of Radiology, Skåne University Hospital, S-20502 Malmö 4. Department of Clinical Sciences Malmö, Lund University, Sweden; Department of Nephrology and Transplantation, Skåne University Hospital, S-20502 Malmö 5. Department of Clinical Sciences Malmö, Lund University, Sweden; Vascular Center, Skåne University Hospital, S-20502 Malmö. Electronic address: johan.wasselius@gmail.com.
Abstract
PURPOSE: The purpose of this retrospective study was to systematically search for acute adverse reactions and long-term complications in all patients that had been administered gadofosveset at our hospital. MATERIALS AND METHODS: We identified 67 gadofosveset administrations during 2006-2009 in 62 patients from 8 to 84years of age. Radiological information system (RIS) and clinical patient records were analyzed for suspected acute adverse reactions and long-term complications including nephrogenic systemic fibrosis (NSF). The gadofosveset doses ranged between 0.024 and 0.060mmol/kg bodyweight with a mean dose of 0.031-mmol/kg bodyweight. Follow-up time of the patients ranged from less than 1year up to 4years with a mean follow-up time of 2.1years. RESULTS: No acute adverse events or technical failures related to the contrast medium were recorded in the RIS. No dermatological and nephrological diseases related to the gadofosveset administration were found in the clinical patient records. Four patients died during follow-up without any apparent relation to the gadofosveset exposure. CONCLUSIONS: Based on our clinical material we conclude that gadofosveset is safe for a mixed patient population with no acute adverse events or any indications of long-term complications during the follow-up time up to four years.
PURPOSE: The purpose of this retrospective study was to systematically search for acute adverse reactions and long-term complications in all patients that had been administered gadofosveset at our hospital. MATERIALS AND METHODS: We identified 67 gadofosveset administrations during 2006-2009 in 62 patients from 8 to 84years of age. Radiological information system (RIS) and clinical patient records were analyzed for suspected acute adverse reactions and long-term complications including nephrogenic systemic fibrosis (NSF). The gadofosveset doses ranged between 0.024 and 0.060mmol/kg bodyweight with a mean dose of 0.031-mmol/kg bodyweight. Follow-up time of the patients ranged from less than 1year up to 4years with a mean follow-up time of 2.1years. RESULTS: No acute adverse events or technical failures related to the contrast medium were recorded in the RIS. No dermatological and nephrological diseases related to the gadofosveset administration were found in the clinical patient records. Four patients died during follow-up without any apparent relation to the gadofosveset exposure. CONCLUSIONS: Based on our clinical material we conclude that gadofosveset is safe for a mixed patient population with no acute adverse events or any indications of long-term complications during the follow-up time up to four years.
Authors: Venkatesh Mani; Nadia Alie; Sarayu Ramachandran; Philip M Robson; Cecilia Besa; Gregory Piazza; Michele Mercuri; Michael Grosso; Bachir Taouli; Samuel Z Goldhaber; Zahi A Fayad Journal: J Vis Exp Date: 2015-06-02 Impact factor: 1.355