Yoshinobu Wakisaka1, Tetsuro Ago2, Masahiro Kamouchi3, Jyunya Kuroda2, Ryu Matsuo2, Jun Hata4, Seiji Gotoh4, Tetsu Isomura5, Hideto Awano5, Kazuo Suzuki5, Kenji Fukuda6, Yasushi Okada7, Yutaka Kiyohara8, Hiroaki Ooboshi9, Takanari Kitazono2. 1. Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. Electronic address: w-yoshi@intmed2.med.kyushu-u.ac.jp. 2. Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 3. Department of Health Care Administration and Management, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 4. Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 5. Molecuence Corporation, Yokohama, Japan. 6. Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Cerebrovascular Disease, Institute of Neuroscience, St Mary's Hospital, Kurume, Japan. 7. Department of Cerebrovascular Medicine and Neurology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan. 8. Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. 9. Department of Internal Medicine, Fukuoka Dental College Medical and Dental Hospital, Japan.
Abstract
BACKGROUND: Ischemic stroke is accompanied by an inflammatory response, which exacerbates brain injury and deteriorates functional outcome. S100A12 is expressed abundantly in granulocytes, and has been implicated to play an important role on inflammatory reactions in various disease states. We aimed to determine the association between plasma S100A12 levels and a functional outcome in patients with acute ischemic stroke. METHODS: We prospectively included 171 patients with acute ischemic stroke within 24h after onset in this study. Plasma samples were collected for the measurement of S100A12 levels. Poor functional outcome was defined as a modified Rankin Scale of 2-6 at day 90 after stroke onset. RESULTS: Of 171 patients, 74 (43.3%) had a poor functional outcome at day 90 after stroke onset. Plasma S100A12 levels on admission were significantly higher in patients with a poor functional outcome (2.1 [1.2-5.1] ng/mL, median [interquartile]) than in those with a favorable outcome (1.1 [0.5-2.0] ng/mL; p<0.001). Multivariate analysis showed that the highest quartile of plasma S100A12 levels on admission showed a significantly higher risk for a poor functional outcome (odds ratio, 4.01; 95% confidence interval, 1.09-16.10; p=0.03) than the lowest quartile. CONCLUSIONS: High plasma S100A12 levels on admission are associated with a poor functional outcome in patients with acute ischemic stroke.
BACKGROUND:Ischemic stroke is accompanied by an inflammatory response, which exacerbates brain injury and deteriorates functional outcome. S100A12 is expressed abundantly in granulocytes, and has been implicated to play an important role on inflammatory reactions in various disease states. We aimed to determine the association between plasma S100A12 levels and a functional outcome in patients with acute ischemic stroke. METHODS: We prospectively included 171 patients with acute ischemic stroke within 24h after onset in this study. Plasma samples were collected for the measurement of S100A12 levels. Poor functional outcome was defined as a modified Rankin Scale of 2-6 at day 90 after stroke onset. RESULTS: Of 171 patients, 74 (43.3%) had a poor functional outcome at day 90 after stroke onset. Plasma S100A12 levels on admission were significantly higher in patients with a poor functional outcome (2.1 [1.2-5.1] ng/mL, median [interquartile]) than in those with a favorable outcome (1.1 [0.5-2.0] ng/mL; p<0.001). Multivariate analysis showed that the highest quartile of plasma S100A12 levels on admission showed a significantly higher risk for a poor functional outcome (odds ratio, 4.01; 95% confidence interval, 1.09-16.10; p=0.03) than the lowest quartile. CONCLUSIONS: High plasma S100A12 levels on admission are associated with a poor functional outcome in patients with acute ischemic stroke.
Authors: Marie Dagonnier; Ira Robin Cooke; Pierre Faou; Tara Kate Sidon; Helen Margaret Dewey; Geoffrey Alan Donnan; David William Howells Journal: Biomark Insights Date: 2017-12-20
Authors: Samantha J Donkel; Boutaina Benaddi; Diederik W J Dippel; Hugo Ten Cate; Moniek P M de Maat Journal: Arterioscler Thromb Vasc Biol Date: 2019-03 Impact factor: 8.311