OBJECTIVE: To conduct a systematic review and meta-analysis on the efficacy of oral non-steroidal anti-inflammatory drugs for rotator cuff tendinopathy. DESIGN: Systematic review. METHOD: A literature search was conducted in 4 databases for randomized controlled trials published until 05/2013, comparing the efficacy of oral anti-inflammatory drugs to any other intervention. Studies characteristics were extracted using a standardized form and the methodological quality was evaluated. Results were summarized qualitatively or quantitatively. RESULTS: The mean methodological score of the 12 included studies was 53.6 ± 8.8%. The majority of studies included acute cases and were underpowered to detect differences in adverse events. Compared to a placebo, oral non-steroidal anti-inflammatory drugs were found to provide short-term pain relief (pooled mean difference: -2.69; 95% confidence interval: -1.96 to -3.41) but not function. Oral anti-inflammatory- drugs and corticosteroids injections have similar short-term efficacy in terms of pain reduction as well as in function (pooled standardized mean difference: 0.09; 95% confidence interval: -0.25 to 0.44). CONCLUSION: Low to moderate grade evidence exists regarding the efficacy of non-steroidal anti-inflammatory drugs for rotator cuff tendinopathy. Oral anti-inflammatory drugs are effective in reducing short-term pain but not function. In terms of pain and function, oral anti-inflammatory drugs in the short term are as effective as corticosteroid injections.
OBJECTIVE: To conduct a systematic review and meta-analysis on the efficacy of oral non-steroidal anti-inflammatory drugs for rotator cuff tendinopathy. DESIGN: Systematic review. METHOD: A literature search was conducted in 4 databases for randomized controlled trials published until 05/2013, comparing the efficacy of oral anti-inflammatory drugs to any other intervention. Studies characteristics were extracted using a standardized form and the methodological quality was evaluated. Results were summarized qualitatively or quantitatively. RESULTS: The mean methodological score of the 12 included studies was 53.6 ± 8.8%. The majority of studies included acute cases and were underpowered to detect differences in adverse events. Compared to a placebo, oral non-steroidal anti-inflammatory drugs were found to provide short-term pain relief (pooled mean difference: -2.69; 95% confidence interval: -1.96 to -3.41) but not function. Oral anti-inflammatory- drugs and corticosteroids injections have similar short-term efficacy in terms of pain reduction as well as in function (pooled standardized mean difference: 0.09; 95% confidence interval: -0.25 to 0.44). CONCLUSION: Low to moderate grade evidence exists regarding the efficacy of non-steroidal anti-inflammatory drugs for rotator cuff tendinopathy. Oral anti-inflammatory drugs are effective in reducing short-term pain but not function. In terms of pain and function, oral anti-inflammatory drugs in the short term are as effective as corticosteroid injections.
Authors: Jacob Gorbaty; Susan M Odum; Meghan K Wally; Rachel B Seymour; Nady Hamid; Joseph R Hsu; Michael Beuhler; Michael J Bosse; Michael Gibbs; Christopher Griggs; Steven Jarrett; Daniel Leas; Tamar Roomian; Michael Runyon; Animita Saha; Bradley Watling; Stephen Wyatt; Ziqing Yu Journal: Arthrosc Sports Med Rehabil Date: 2021-02-03
Authors: Yazed AlRuthia; Sultan Alghadeer; Bander Balkhi; Haya M Almalag; Hana Alsobayel; Faris Alodaibi; Fakhr Alayoubi; Amal S Alkhamali; Samar Alshuwairikh; Futoun N Alqahtani; Hisham Alsanawi Journal: Saudi Pharm J Date: 2019-06-10 Impact factor: 4.330
Authors: Jung Hun Kim; Se Hee Kim; Hae-Rim Kim; Sang-Heon Lee; So Young Yoon; Jung-Hyun Yang; Young Bum Yoo; Kyoung Sik Park; Sang Eun Nam; Semie Hong; Hong Ki Min Journal: Sci Rep Date: 2020-10-08 Impact factor: 4.379