Literature DB >> 2462352

Bacterial epitopes involved in the induction of reactive arthritis.

H Stieglitz1, S Fosmire, P E Lipsky.   

Abstract

A panel of documented arthritogenic Shigella flexneri strains as well as an epidemic-associated non-arthritogenic Shigella sonnei control was used to identify a 2-megadalton plasmid specific to the arthritogenic strains. The plasmid, pHS-2, contains a DNA sequence that encodes a 22-amino acid polypeptide encompassing a pentapeptide homologous to part of the polymorphic region of the alpha-1 domain of HLA-B27. These results suggest that molecular mimicry between arthritogenic bacterial-encoded epitopes and the HLA-B27 molecule may play a role in the development of reactive arthritis.

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Year:  1988        PMID： 2462352     DOI： 10.1016/0002-9343(88)90387-7

Source DB:  PubMed          Journal:  Am J Med        ISSN： 0002-9343            Impact factor:   4.965


  7 in total

1.  Autoantibodies to the HLA-B27 sequence cross-react with the hypothetical peptide from the arthritis-associated Shigella plasmid.

Authors:  N Tsuchiya; G Husby; R C Williams; H Stieglitz; P E Lipsky; R D Inman
Journal:  J Clin Invest       Date:  1990-10       Impact factor: 14.808

2.  Recognition of binding sites on Candida albicans by monoclonal antibodies to human leukocyte antigens.

Authors:  C L Mayer; R D Diamond; J E Edwards
Journal:  Infect Immun       Date:  1990-11       Impact factor: 3.441

Review 3.  Molecular mimicry: any role in the pathogenesis of spondyloarthropathies?

Authors:  R Lahesmaa; M Skurnik; P Toivanen
Journal:  Immunol Res       Date:  1993       Impact factor: 2.829

4.  Molecular mimickry between HLA B27 and Yersinia, Salmonella, Shigella and Klebsiella within the same region of HLA alpha 1-helix.

Authors:  R Lahesmaa; M Skurnik; M Vaara; M Leirisalo-Repo; M Nissilä; K Granfors; P Toivanen
Journal:  Clin Exp Immunol       Date:  1991-12       Impact factor: 4.330

5.  Antibody activity in ankylosing spondylitis sera to two sites on HLA B27.1 at the MHC groove region (within sequence 65-85), and to a Klebsiella pneumoniae nitrogenase reductase peptide (within sequence 181-199).

Authors:  C Ewing; R Ebringer; G Tribbick; H M Geysen
Journal:  J Exp Med       Date:  1990-05-01       Impact factor: 14.307

6.  The anti-shigellosis activity of the methanol extract of Picralima nitida on Shigella dysenteriae type I induced diarrhoea in rats.

Authors:  Laure Brigitte Mabeku Kouitcheu; Joseph Lebel Tamesse; Jacques Kouam
Journal:  BMC Complement Altern Med       Date:  2013-08-17       Impact factor: 3.659

7.  Screening of anti-microbial, anti-biofilm activity, and cytotoxicity analysis of a designed polyherbal formulation against shigellosis.

Authors:  Devendra Singh; Deepmala Sharma; Vishnu Agarwal
Journal:  J Ayurveda Integr Med       Date:  2021-11-09
  7 in total

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