Literature DB >> 24619000

Rad17, the clamp loader that loads more than clamps.

Tanya T Paull1, Ji-Hoon Lee.   

Abstract

Rad17 is best known as a checkpoint clamp loader in the activation of ATR kinase signaling. A new study in The EMBO Journal suggests that it also plays a role in initial recruitment of the MRN complex to sites of DNA double-strand breaks, thereby promoting early ATM checkpoint responses and homologous recombination repair.

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Year:  2014        PMID： 24619000      PMCID： PMC4194106          DOI： 10.1002/embj.201488223

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  12 in total

1.  Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks.

Authors:  Qinhong Wang; Michael Goldstein; Peter Alexander; Timothy P Wakeman; Tao Sun; Junjie Feng; Zhenkun Lou; Michael B Kastan; Xiao-Fan Wang
Journal:  EMBO J       Date:  2014-02-16       Impact factor: 11.598

2.  Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.

Authors:  Arkady Celeste; Oscar Fernandez-Capetillo; Michael J Kruhlak; Duane R Pilch; David W Staudt; Alicia Lee; Robert F Bonner; William M Bonner; André Nussenzweig
Journal:  Nat Cell Biol       Date:  2003-07       Impact factor: 28.824

3.  MDC1 is required for the intra-S-phase DNA damage checkpoint.

Authors:  Michal Goldberg; Manuel Stucki; Jacob Falck; Damien D'Amours; Dinah Rahman; Darryl Pappin; Jiri Bartek; Stephen P Jackson
Journal:  Nature       Date:  2003-02-27       Impact factor: 49.962

4.  NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors.

Authors:  Xingzhi Xu; David F Stern
Journal:  FASEB J       Date:  2003-10       Impact factor: 5.191

5.  The 9-1-1 DNA clamp is required for immunoglobulin gene conversion.

Authors:  Alihossein Saberi; Makoto Nakahara; Julian E Sale; Koji Kikuchi; Hiroshi Arakawa; Jean-Marie Buerstedde; Kenichi Yamamoto; Shunichi Takeda; Eiichiro Sonoda
Journal:  Mol Cell Biol       Date:  2008-07-28       Impact factor: 4.272

6.  Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention.

Authors:  Claudia Lukas; Fredrik Melander; Manuel Stucki; Jacob Falck; Simon Bekker-Jensen; Michal Goldberg; Yaniv Lerenthal; Stephen P Jackson; Jiri Bartek; Jiri Lukas
Journal:  EMBO J       Date:  2004-06-17       Impact factor: 11.598

7.  hRad9 rapidly binds DNA containing double-strand breaks and is required for damage-dependent topoisomerase II beta binding protein 1 focus formation.

Authors:  Deborah A Greer; Blair D A Besley; Katherine B Kennedy; Scott Davey
Journal:  Cancer Res       Date:  2003-08-15       Impact factor: 12.701

Review 8.  Activation and regulation of ATM kinase activity in response to DNA double-strand breaks.

Authors:  J-H Lee; T T Paull
Journal:  Oncogene       Date:  2007-12-10       Impact factor: 9.867

Review 9.  A tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1.

Authors:  Vasundhara M Navadgi-Patil; Peter M Burgers
Journal:  DNA Repair (Amst)       Date:  2009-05-22

10.  A novel role for Rad17 in homologous recombination.

Authors:  Katsuaki Nishino; Eri Inoue; Shunya Takada; Takuya Abe; Motomu Akita; Akari Yoshimura; Shusuke Tada; Masahiko Kobayashi; Ken-Ichi Yamamoto; Masayuki Seki; Takemi Enomoto
Journal:  Genes Genet Syst       Date:  2008-10       Impact factor: 1.517
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