Literature DB >> 18066086

Activation and regulation of ATM kinase activity in response to DNA double-strand breaks.

J-H Lee1, T T Paull.   

Abstract

The ataxia-telangiectasia-mutated (ATM) protein kinase is rapidly and specifically activated in response to DNA double-strand breaks in eukaryotic cells. In this review, we summarize recent insights into the mechanism of ATM activation, focusing on the role of the Mre11/Rad50/Nbs1 (MRN) complex in this process. We also compare observations of the ATM activation process in different biological systems and highlight potential candidates for cellular factors that may participate in regulating ATM activity in human cells.

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Year:  2007        PMID： 18066086     DOI： 10.1038/sj.onc.1210872

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  256 in total

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2.  ATM-dependent phosphorylation of the checkpoint clamp regulates repair pathways and maintains genomic stability.

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Journal:  Cell Cycle       Date:  2012-05-01       Impact factor: 4.534

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Journal:  Age (Dordr)       Date:  2011-09-23

4.  Radiobiological Response of Cervical Cancer Cell Line in Low Dose Region: Evidence of Low Dose Hypersensitivity (HRS) and Induced Radioresistance (IRR).

Authors:  Saikat Das; Rabiraja Singh; Daicy George; T S Vijaykumar; Subhashini John
Journal:  J Clin Diagn Res       Date:  2015-06-01

5.  Poly(ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in mammary tumors.

Authors:  Yong Tang; Hossein A Hamed; Andrew Poklepovic; Yun Dai; Steven Grant; Paul Dent
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Review 6.  Double-strand break repair: 53BP1 comes into focus.

Authors:  Stephanie Panier; Simon J Boulton
Journal:  Nat Rev Mol Cell Biol       Date:  2013-12-11       Impact factor: 94.444

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Authors:  Amanda K Ashley; Meena Shrivastav; Jingyi Nie; Courtney Amerin; Kyle Troksa; Jason G Glanzer; Shengqin Liu; Stephen O Opiyo; Diana D Dimitrova; Phuong Le; Brock Sishc; Susan M Bailey; Greg G Oakley; Jac A Nickoloff
Journal:  DNA Repair (Amst)       Date:  2014-05-10

8.  PNAS-4, an Early DNA Damage Response Gene, Induces S Phase Arrest and Apoptosis by Activating Checkpoint Kinases in Lung Cancer Cells.

Authors:  Zhu Yuan; Wenhao Guo; Jun Yang; Lei Li; Meiliang Wang; Yi Lei; Yang Wan; Xinyu Zhao; Na Luo; Ping Cheng; Xinyu Liu; Chunlai Nie; Yong Peng; Aiping Tong; Yuquan Wei
Journal:  J Biol Chem       Date:  2015-04-27       Impact factor: 5.157

9.  A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination.

Authors:  Kayleigh Herrick-Reynolds; Bharat Vaidyanathan; Joseph N Pucella; Bao Q Vuong; Anna J Ucher; Nina M Donghia; Xiwen Gu; Laura Nicolas; Urszula Nowak; Numa Rahman; Matthew P Strout; Kevin D Mills; Janet Stavnezer; Jayanta Chaudhuri
Journal:  Nat Immunol       Date:  2013-10-06       Impact factor: 25.606

10.  Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation.

Authors:  Seema S Lakdawala; Rachel A Schwartz; Kevin Ferenchak; Christian T Carson; Brian P McSharry; Gavin W Wilkinson; Matthew D Weitzman
Journal:  J Virol       Date:  2008-06-18       Impact factor: 5.103
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