| Literature DB >> 24615135 |
Graziele Pereira Oliveira1, André Tavares Silva Fernandes1, Felipe Lopes de Assis1, Pedro Augusto Alves1, Ana Paula Moreira Franco Luiz1, Leandra Barcelos Figueiredo1, Cláudia Maria Costa de Almeida1, Carlos Eurico Pires Ferreira Travassos1, Giliane de Souza Trindade1, Jônatas Santos Abrahão1, Erna Geessien Kroon2.
Abstract
Bovine vaccinia (BV) is an emerging zoonosis caused by the Vaccinia virus (VACV), genus Orthopoxvirus (OPV), Poxviridae family. In general, human cases are related to direct contact with sick cattle but there is a lack of information about human-to-human transmission of VACV during BV outbreaks. In this study, we epidemiologically and molecularly show a case of VACV transmission between humans in São Francisco de Itabapoana County, Rio de Janeiro state. Our group collected samples from the patients, a 49-year-old patient and his son. Our results showed that patients had developed anti-OPV IgG or IgM antibodies and presented neutralizing antibodies against OPV. The VACV isolates displayed high identity (99.9%) and were grouped in the same phylogenetic tree branch. Our data indicate that human-to-human VACV transmission occurred during a BV outbreak, raising new questions about the risk factors of the VACV transmission chain. © The American Society of Tropical Medicine and Hygiene.Entities:
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Year: 2014 PMID： 24615135 PMCID： PMC4047723 DOI： 10.4269/ajtmh.13-0621
Source DB: PubMed Journal: Am J Trop Med Hyg ISSN： 0002-9637 Impact factor: 2.345