Literature DB >> 24614084

The protein phosphatase PhzA of A. fumigatus is involved in oxidative stress tolerance and fungal virulence.

Laetitia Muszkieta1, Steven de Jesus Carrion2, Pauline Robinet3, Rémi Beau4, Carole Elbim3, Eric Pearlman2, Jean-Paul Latgé4.   

Abstract

Protein phosphatases Z that are unique to the fungal kingdom have been associated to resistance to high salt concentration, cell wall integrity, cell cycle regulation, and oxidative stress in fungi. In Aspergillus fumigatus, it was shown that PHZA is under the control of the transcription factor Skn7 and is only involved in the control of the oxidative stress. Accordingly, the ΔphzA mutant showed a defect in virulence in an experimental model of corneal infection in immunocompetent animals and that the impact on susceptibility to cell wall drugs is only secondary.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Aspergillus fumigatus; Corneal infection; Oxidative stress; Phosphatase; Virulence

Mesh：

Substances：

Year:  2014        PMID： 24614084      PMCID： PMC4503245          DOI： 10.1016/j.fgb.2014.02.009

Source DB:  PubMed          Journal:  Fungal Genet Biol        ISSN： 1087-1845            Impact factor:   3.495


  27 in total

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Journal:  Appl Environ Microbiol       Date:  2010-07-23       Impact factor: 4.792

2.  Mitochondrial sorting and assembly machinery subunit Sam37 in Candida albicans: insight into the roles of mitochondria in fitness, cell wall integrity, and virulence.

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Journal:  Eukaryot Cell       Date:  2012-01-27

3.  The polymorphism of protein phosphatase Z1 gene in Candida albicans.

Authors:  László Kovács; Ilona Farkas; László Majoros; Márton Miskei; István Pócsi; Viktor Dombrádi
Journal:  J Basic Microbiol       Date:  2010-12       Impact factor: 2.281

4.  Functional analysis of the superoxide dismutase family in Aspergillus fumigatus.

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Journal:  Mol Microbiol       Date:  2010-02       Impact factor: 3.501

5.  Fungal antioxidant pathways promote survival against neutrophils during infection.

Authors:  Sixto M Leal; Chairut Vareechon; Susan Cowden; Brian A Cobb; Jean-Paul Latgé; Michelle Momany; Eric Pearlman
Journal:  J Clin Invest       Date:  2012-06-18       Impact factor: 14.808

6.  Cutaneous model of invasive aspergillosis.

Authors:  Ronen Ben-Ami; Russell E Lewis; Konstantinos Leventakos; Jean-Paul Latgé; Dimitrios P Kontoyiannis
Journal:  Antimicrob Agents Chemother       Date:  2010-02-09       Impact factor: 5.191

7.  Conserved Ser/Arg-rich motif in PPZ orthologs from fungi is important for its role in cation tolerance.

Authors:  Anupriya Minhas; Anupam Sharma; Harsimran Kaur; Yashpal Rawal; Kaliannan Ganesan; Alok K Mondal
Journal:  J Biol Chem       Date:  2012-01-09       Impact factor: 5.157

8.  Association of the Skn7 and Yap1 transcription factors in the Saccharomyces cerevisiae oxidative stress response.

Authors:  K E Mulford; J S Fassler
Journal:  Eukaryot Cell       Date:  2011-04-08

9.  Protein phosphatase Z modulates oxidative stress response in fungi.

Authors:  Éva Leiter; Asier González; Éva Erdei; Carlos Casado; László Kovács; Csaba Ádám; Judit Oláh; Márton Miskei; Monika Molnar; Ilona Farkas; Zsuzsanna Hamari; Joaquín Ariño; István Pócsi; Viktor Dombrádi
Journal:  Fungal Genet Biol       Date:  2012-06-30       Impact factor: 3.495

10.  Comparative lipidomics in clinical isolates of Candida albicans reveal crosstalk between mitochondria, cell wall integrity and azole resistance.

Authors:  Ashutosh Singh; Vipin Yadav; Rajendra Prasad
Journal:  PLoS One       Date:  2012-06-27       Impact factor: 3.240
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  6 in total

1.  Systematic Global Analysis of Genes Encoding Protein Phosphatases in Aspergillus fumigatus.

Authors:  Lizziane K Winkelströter; Stephen K Dolan; Thaila Fernanda Dos Reis; Vinícius Leite Pedro Bom; Patrícia Alves de Castro; Daisuke Hagiwara; Raneem Alowni; Gary W Jones; Sean Doyle; Neil Andrew Brown; Gustavo H Goldman
Journal:  G3 (Bethesda)       Date:  2015-05-05       Impact factor: 3.154

2.  Heavy Metal-Induced Expression of PcaA Provides Cadmium Tolerance to Aspergillus fumigatus and Supports Its Virulence in the Galleria mellonella Model.

Authors:  Fruzsina Bakti; Christoph Sasse; Thorsten Heinekamp; István Pócsi; Gerhard H Braus
Journal:  Front Microbiol       Date:  2018-04-13       Impact factor: 5.640

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Authors:  Aroa Rodriguez-Iglesias; Monika Schmoll
Journal:  Sci Rep       Date:  2019-07-29       Impact factor: 4.379

4.  Prospecting Biomarkers for Diagnostic and Therapeutic Approaches in Pythiosis.

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Journal:  J Fungi (Basel)       Date:  2021-05-28

5.  Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus.

Authors:  Kevin J Sheridan; Beatrix Elisabeth Lechner; Grainne O' Keeffe; Markus A Keller; Ernst R Werner; Herbert Lindner; Gary W Jones; Hubertus Haas; Sean Doyle
Journal:  Sci Rep       Date:  2016-10-17       Impact factor: 4.379

6.  Deletion of the fungus specific protein phosphatase Z1 exaggerates the oxidative stress response in Candida albicans.

Authors:  Krisztina Szabó; Ágnes Jakab; Szilárd Póliska; Katalin Petrényi; Katalin Kovács; Lama Hasan Bou Issa; Tamás Emri; István Pócsi; Viktor Dombrádi
Journal:  BMC Genomics       Date:  2019-11-19       Impact factor: 3.969
  6 in total

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