Ding Ding1, Qianhua Zhao1, Qihao Guo1, Haijiao Meng1, Bei Wang1, Jianfeng Luo2, James A Mortimer3, Amy R Borenstein3, Zhen Hong4. 1. Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China. 2. Department of Health Statistics, School of Public Health, Fudan University, Shanghai, China. 3. Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, USA. 4. Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China. Electronic address: profzhong@sina.com.cn.
Abstract
BACKGROUND: Substantial variations in the prevalence of mild cognitive impairment (MCI) have been reported, although mostly in Western countries. Less is known about MCI in the Chinese population. METHODS: We clinically and neuropsychologically evaluated 3141 community residents ≥60 years of age. Diagnoses of MCI and its subtypes were made using standard criteria via consensus diagnosis. RESULTS: Among 2985 nondemented individuals, 601 were diagnosed with MCI, resulting in a prevalence of 20.1% for total MCI, 13.2% for amnestic MCI (aMCI), and 7.0% for non-amnestic MCI (naMCI). The proportions of MCI subtypes were: aMCI single domain (SD), 38.9%; aMCI multiple domains (MD), 26.5%; naMCI-SD, 25.0%; and naMCI-MD, 9.6%. The prevalence of aMCI-MD increased rapidly with age in women APOE ε4 carriers (from 60 to 69 years to ≥80 years, 3.1%-33.3%, P < .001). CONCLUSIONS: Our findings suggest that 20% of Chinese elderly are affected by MCI. Prospective studies in China are needed to examine progression to dementia and related risk factors.
BACKGROUND: Substantial variations in the prevalence of mild cognitive impairment (MCI) have been reported, although mostly in Western countries. Less is known about MCI in the Chinese population. METHODS: We clinically and neuropsychologically evaluated 3141 community residents ≥60 years of age. Diagnoses of MCI and its subtypes were made using standard criteria via consensus diagnosis. RESULTS: Among 2985 nondemented individuals, 601 were diagnosed with MCI, resulting in a prevalence of 20.1% for total MCI, 13.2% for amnestic MCI (aMCI), and 7.0% for non-amnestic MCI (naMCI). The proportions of MCI subtypes were: aMCI single domain (SD), 38.9%; aMCI multiple domains (MD), 26.5%; naMCI-SD, 25.0%; and naMCI-MD, 9.6%. The prevalence of aMCI-MD increased rapidly with age in womenAPOE ε4 carriers (from 60 to 69 years to ≥80 years, 3.1%-33.3%, P < .001). CONCLUSIONS: Our findings suggest that 20% of Chinese elderly are affected by MCI. Prospective studies in China are needed to examine progression to dementia and related risk factors.
Authors: Ronald C Petersen; Oscar Lopez; Melissa J Armstrong; Thomas S D Getchius; Mary Ganguli; David Gloss; Gary S Gronseth; Daniel Marson; Tamara Pringsheim; Gregory S Day; Mark Sager; James Stevens; Alexander Rae-Grant Journal: Neurology Date: 2017-12-27 Impact factor: 9.910
Authors: Qianhua Zhao; Rosebud O Roberts; Ding Ding; Ruth Cha; Qihao Guo; Haijiao Meng; Jianfeng Luo; Mary M Machulda; V Shane Pankratz; Bei Wang; Teresa J H Christianson; Jeremiah A Aakre; David S Knopman; Bradley F Boeve; Zhen Hong; Ronald C Petersen Journal: J Alzheimers Dis Date: 2015 Impact factor: 4.472