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Literature DB >> 24613573

The IL-6 feed-forward loop: a driver of tumorigenesis.

Qing Chang¹, Laura Daly¹, Jacqueline Bromberg².

Abstract

IL-6 signaling plays a prominent role in tumorigenesis and metastasis. In this review we discuss the recent evidence describing the tumor intrinsic and extrinsic functions of this signaling pathway. Although blockade of this pathway in pre-clinical models leads to a reduction in tumor growth and metastasis, its clinical success is less evident. Thus, identifying the features of tumors/patients that predict response to anti-IL6 therapy are needed.

Entities: Disease Gene Species

Keywords: Cancer; Metastasis; Microenvironment

Mesh：

Substances：

Year: 2014 PMID： 24613573 DOI： 10.1016/j.smim.2014.01.007

Source DB: PubMed Journal: Semin Immunol ISSN： 1044-5323 Impact factor: 11.130

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Cited

42 in total

1. Ixodes ricinus salivary serpin IRS-2 affects Th17 differentiation via inhibition of the interleukin-6/STAT-3 signaling pathway.

Authors: Jana Páleníková; Jaroslava Lieskovská; Helena Langhansová; Michalis Kotsyfakis; Jindřich Chmelař; Jan Kopecký
Journal: Infect Immun Date: 2015-02-23 Impact factor: 3.441

2. Immune checkpoint inhibitor-induced rheumatoid arthritis: insights into an increasingly common aetiology of polyarthritis.

Authors: Timothy Shun Him Kwok; Mary Jane Bell
Journal: BMJ Case Rep Date: 2019-02-27

The IL-6 feed-forward loop: a driver of tumorigenesis.

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2. Immune checkpoint inhibitor-induced rheumatoid arthritis: insights into an increasingly common aetiology of polyarthritis.

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Review 8. NF-κB, inflammation, immunity and cancer: coming of age.

9. Inflammation, cytokines, the IL-17/IL-6/STAT3/NF-κB axis, and tumorigenesis.

Review 10. Important Role of the IL-32 Inflammatory Network in the Host Response against Viral Infection.