Sarah E Ackerman1, Olivia A Blackburn1,2, François Marchildon1, Paul Cohen3,4. 1. Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA. 2. Weill Cornell/Rockefeller/Sloan Kettering Tri-Institutional MD-PhD Program, New York, NY, USA. 3. Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, USA. pcohen@rockefeller.edu. 4. The Rockefeller University, 1230 York Avenue, Box 223, New York, NY, 10065, USA. pcohen@rockefeller.edu.
Abstract
PURPOSE OF REVIEW: Adipocytes have adapted to store energy in the form of lipid and also secrete circulating factors called adipokines that signal to other tissues to coordinate energy homeostasis. These functions are disrupted in the setting of obesity, promoting the development of diseases such as diabetes, cardiovascular disease, and cancer. RECENT FINDINGS: Obesity is linked to an increased risk of many types of cancer and increased cancer-related mortality. The basis for the striking association between obesity and cancer is not well understood. Here, we review the cellular and molecular pathways that appear to be involved in obesity-driven cancer. We also describe possible therapeutic considerations and highlight important unanswered questions in the field.
PURPOSE OF REVIEW: Adipocytes have adapted to store energy in the form of lipid and also secrete circulating factors called adipokines that signal to other tissues to coordinate energy homeostasis. These functions are disrupted in the setting of obesity, promoting the development of diseases such as diabetes, cardiovascular disease, and cancer. RECENT FINDINGS:Obesity is linked to an increased risk of many types of cancer and increased cancer-related mortality. The basis for the striking association between obesity and cancer is not well understood. Here, we review the cellular and molecular pathways that appear to be involved in obesity-driven cancer. We also describe possible therapeutic considerations and highlight important unanswered questions in the field.
Authors: Joana Pinto Couto; Laura Daly; Ana Almeida; Jeffrey A Knauf; James A Fagin; Manuel Sobrinho-Simões; Jorge Lima; Valdemar Máximo; Paula Soares; David Lyden; Jacqueline F Bromberg Journal: Proc Natl Acad Sci U S A Date: 2012-08-13 Impact factor: 11.205
Authors: Erik R Nelson; Suzanne E Wardell; Jeff S Jasper; Sunghee Park; Sunil Suchindran; Matthew K Howe; Nicole J Carver; Ruchita V Pillai; Patrick M Sullivan; Varun Sondhi; Michihisa Umetani; Joseph Geradts; Donald P McDonnell Journal: Science Date: 2013-11-29 Impact factor: 47.728
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Authors: Sean Wharton; David C W Lau; Michael Vallis; Arya M Sharma; Laurent Biertho; Denise Campbell-Scherer; Kristi Adamo; Angela Alberga; Rhonda Bell; Normand Boulé; Elaine Boyling; Jennifer Brown; Betty Calam; Carol Clarke; Lindsay Crowshoe; Dennis Divalentino; Mary Forhan; Yoni Freedhoff; Michel Gagner; Stephen Glazer; Cindy Grand; Michael Green; Margaret Hahn; Raed Hawa; Rita Henderson; Dennis Hong; Pam Hung; Ian Janssen; Kristen Jacklin; Carlene Johnson-Stoklossa; Amy Kemp; Sara Kirk; Jennifer Kuk; Marie-France Langlois; Scott Lear; Ashley McInnes; David Macklin; Leen Naji; Priya Manjoo; Marie-Philippe Morin; Kara Nerenberg; Ian Patton; Sue Pedersen; Leticia Pereira; Helena Piccinini-Vallis; Megha Poddar; Paul Poirier; Denis Prud'homme; Ximena Ramos Salas; Christian Rueda-Clausen; Shelly Russell-Mayhew; Judy Shiau; Diana Sherifali; John Sievenpiper; Sanjeev Sockalingam; Valerie Taylor; Ellen Toth; Laurie Twells; Richard Tytus; Shahebina Walji; Leah Walker; Sonja Wicklum Journal: CMAJ Date: 2020-12-07 Impact factor: 8.262
Authors: Sean Wharton; David C W Lau; Michael Vallis; Arya M Sharma; Laurent Biertho; Denise Campbell-Scherer; Kristi Adamo; Angela Alberga; Rhonda Bell; Normand Boulé; Elaine Boyling; Jennifer Brown; Betty Calam; Carol Clarke; Lindsay Crowshoe; Dennis Divalentino; Mary Forhan; Yoni Freedhoff; Michel Gagner; Stephen Glazer; Cindy Grand; Michael Green; Margaret Hahn; Raed Hawa; Rita Henderson; Dennis Hong; Pam Hung; Ian Janssen; Kristen Jacklin; Carlene Johnson-Stoklossa; Amy Kemp; Sara Kirk; Jennifer Kuk; Marie-France Langlois; Scott Lear; Ashley McInnes; David Macklin; Leen Naji; Priya Manjoo; Marie-Philippe Morin; Kara Nerenberg; Ian Patton; Sue Pedersen; Leticia Pereira; Helena Piccinini-Vallis; Megha Poddar; Paul Poirier; Denis Prud'homme; Ximena Ramos Salas; Christian Rueda-Clausen; Shelly Russell-Mayhew; Judy Shiau; Diana Sherifali; John Sievenpiper; Sanjeev Sockalingam; Valerie Taylor; Ellen Toth; Laurie Twells; Richard Tytus; Shahebina Walji; Leah Walker; Sonja Wicklum Journal: CMAJ Date: 2020-08-04 Impact factor: 8.262
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