Sarah Pitts1, Emily Blood2, Amy Divasta3, Catherine M Gordon4. 1. Division of Adolescent/Young Adult Medicine and Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts. Electronic address: sarah.pitts@childrens.harvard.edu. 2. Clinical Research Center and Division of Adolescent/Young Adult Medicine, Boston Children's Hospital, Boston, Massachusetts. 3. Division of Adolescent/Young Adult Medicine and Division of Gynecology, Boston Children's Hospital, Boston, Massachusetts. 4. Division of Adolescent Medicine, Hasbro Children's Hospital, Providence, Rhode Island.
Abstract
PURPOSE: To evaluate mediators of resumption of menses (ROM) in adolescents with anorexia nervosa (AN). METHODS:Anthropometrics, body composition by dual-energy X-ray absorptiometry, hormonal studies, and responses to mental health screens were obtained at 6-month intervals for 18 months in 37 adolescents with AN randomized to the placebo arm of a double-blind treatment trial. Outcomes were compared between subjects with menstrual recovery and those without. RESULTS: Twenty-four subjects (65%) had ROM. Higher percentage body fat was associated with ROM (odds ratio, 1.19; 95% confidence interval, 1.06, 1.33; p < .01), as was body mass index and percent median body weight. Estradiol ≥30 ng/mL alone did not predict menses (p = .08) but was associated with ROM when coupled with percent mean body weight (odds ratio, 2.49; 95% confidence interval, 1.09, 5.65; p = .03). Changes in leptin, cortisol, and mental health were not associated with return of menses. CONCLUSIONS: Percentage body fat may be an additional, useful clinical assessment to follow in caring for adolescents with AN.
RCT Entities:
PURPOSE: To evaluate mediators of resumption of menses (ROM) in adolescents with anorexia nervosa (AN). METHODS: Anthropometrics, body composition by dual-energy X-ray absorptiometry, hormonal studies, and responses to mental health screens were obtained at 6-month intervals for 18 months in 37 adolescents with AN randomized to the placebo arm of a double-blind treatment trial. Outcomes were compared between subjects with menstrual recovery and those without. RESULTS: Twenty-four subjects (65%) had ROM. Higher percentage body fat was associated with ROM (odds ratio, 1.19; 95% confidence interval, 1.06, 1.33; p < .01), as was body mass index and percent median body weight. Estradiol ≥30 ng/mL alone did not predict menses (p = .08) but was associated with ROM when coupled with percent mean body weight (odds ratio, 2.49; 95% confidence interval, 1.09, 5.65; p = .03). Changes in leptin, cortisol, and mental health were not associated with return of menses. CONCLUSIONS: Percentage body fat may be an additional, useful clinical assessment to follow in caring for adolescents with AN.
Authors: Amy D Divasta; Henry A Feldman; Courtney Giancaterino; Clifford J Rosen; Meryl S Leboff; Catherine M Gordon Journal: Metabolism Date: 2012-01-16 Impact factor: 8.694
Authors: Corrine K Welt; Jean L Chan; John Bullen; Robyn Murphy; Patricia Smith; Alex M DePaoli; Aspasia Karalis; Christos S Mantzoros Journal: N Engl J Med Date: 2004-09-02 Impact factor: 91.245