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Literature DB >> 2461300

The achaete-scute gene complex of Drosophila melanogaster comprises four homologous genes.

Abstract

We have determined the nucleotide sequence of two genes of the achaete - scute complex (AS-C) and show that they are homologous to two previously sequenced members of the same locus. These four genes are interspersed with other transcription units of unknown function. We also study the expression of one of these genes by in situ hybridization and compare it with the other three genes. We suggest that the complete function ascribed to the AS-C by genetic experiments is carried out by the four homologous genes. We discuss the possible biochemical function of the AS-C in neurogenesis in the light of the homologies of the four genes with the mammalian myc family.

Entities: Chemical

Mesh：

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Year: 1988 PMID： 2461300 PMCID： PMC457132 DOI： 10.1002/j.1460-2075.1988.tb03108.x

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

31 in total

1. Rates of formation and thermal stabilities of RNA:DNA and DNA:DNA duplexes at high concentrations of formamide.

Authors: J Casey; N Davidson
Journal: Nucleic Acids Res Date: 1977 Impact factor: 16.971

2. Genes in subdivision 1B of the Drosophila melanogaster X-chromosome and their influence on neural development.

Authors: F Jiménez; J A Campos-Ortega
Journal: J Neurogenet Date: 1987-06 Impact factor: 1.250

3. The current status and portability of our sequence handling software.

Authors: R Staden
Journal: Nucleic Acids Res Date: 1986-01-10 Impact factor: 16.971

4. Expression and function of the segmentation gene fushi tarazu during Drosophila neurogenesis.

Authors: C Q Doe; Y Hiromi; W J Gehring; C S Goodman
Journal: Science Date: 1988-01-08 Impact factor: 47.728

5. A new class of yeast transcriptional activators.

Authors: J Ma; M Ptashne
Journal: Cell Date: 1987-10-09 Impact factor: 41.582

6. "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.

Authors: A P Feinberg; B Vogelstein
Journal: Anal Biochem Date: 1984-02 Impact factor: 3.365

7. New M13 vectors for cloning.

Authors: J Messing
Journal: Methods Enzymol Date: 1983 Impact factor: 1.600

8. Early events in insect neurogenesis. II. The role of cell interactions and cell lineage in the determination of neuronal precursor cells.

Authors: C Q Doe; C S Goodman
Journal: Dev Biol Date: 1985-09 Impact factor: 3.582

9. Molecular genetics of the achaete-scute gene complex of D. melanogaster.

Authors: S Campuzano; L Carramolino; C V Cabrera; M Ruíz-Gómez; R Villares; A Boronat; J Modolell
Journal: Cell Date: 1985-02 Impact factor: 41.582

10. A rapid single-stranded cloning strategy for producing a sequential series of overlapping clones for use in DNA sequencing: application to sequencing the corn mitochondrial 18 S rDNA.

Authors: R M Dale; B A McClure; J P Houchins
Journal: Plasmid Date: 1985-01 Impact factor: 3.466

74 in total

The achaete-scute gene complex of Drosophila melanogaster comprises four homologous genes.

1. Rates of formation and thermal stabilities of RNA:DNA and DNA:DNA duplexes at high concentrations of formamide.

2. Genes in subdivision 1B of the Drosophila melanogaster X-chromosome and their influence on neural development.

3. The current status and portability of our sequence handling software.

4. Expression and function of the segmentation gene fushi tarazu during Drosophila neurogenesis.

5. A new class of yeast transcriptional activators.

6. "A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum.

7. New M13 vectors for cloning.

8. Early events in insect neurogenesis. II. The role of cell interactions and cell lineage in the determination of neuronal precursor cells.

9. Molecular genetics of the achaete-scute gene complex of D. melanogaster.

10. A rapid single-stranded cloning strategy for producing a sequential series of overlapping clones for use in DNA sequencing: application to sequencing the corn mitochondrial 18 S rDNA.

Review 1. Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms.

2. Tufted is a gain-of-function allele that promotes ectopic expression of the proneural gene amos in Drosophila.

3. Genes involved in the development of bristles and hairs in Drosophila melanogaster.

4. Involvement of Hydra achaete-scute gene CnASH in the differentiation pathway of sensory neurons in the tentacles.

5. The Enhancer of split [E(spl)] locus of Drosophila encodes seven independent helix-loop-helix proteins.

6. A helix-loop-helix protein related to the immunoglobulin E box-binding proteins.

7. Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains.

8. Differential trans activation associated with the muscle regulatory factors MyoD1, myogenin, and MRF4.

9. Inefficient homooligomerization contributes to the dependence of myogenin on E2A products for efficient DNA binding.

10. Mutagenesis of the myogenin basic region identifies an ancient protein motif critical for activation of myogenesis.