Literature DB >> 24612344

New insights into an old organelle: meeting report on biology of cilia and flagella.

Piali Sengupta1, Maureen M Barr.   

Abstract

The rising interest of the scientific community in cilia biology was evident from the fact that registration for the third FASEB conference on 'The Biology of Cilia and Flagella' closed out before the early bird deadline. Cilia and flagella are organelles of profound medical importance; defects in their structure or function result in a plethora of human diseases called ciliopathies. 240 clinicians and basic scientists from around the world gathered from 23 June 2013 to 28 June 2013 at Sheraton at the Falls, Niagara Falls, NY to present and discuss their research on this intensely studied subcellular structure. The meeting was organized by Gregory Pazour (University of Massachusetts Medical School), Bradley Yoder (University of Alabama-Birmingham), and Maureen Barr (Rutgers University) and was sponsored by the Federation of American Societies for Experimental Biology (FASEB). Here, we report highlights, points of discussion, and emerging themes from this exciting meeting.
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  ADPKD; ARPKD; BBS; C. elegans; Chlamydomonas; Drosophila; Hedgehog; JBTS; MKS; NPHP; STED; STORM; basal body; cilia; ciliopathy; cryo-EM; ectosomes; flagella; intraflagellar transport (IFT); microscopy; microtubule; signal transduction; transition fiber; transition zone; tubulin post translational modification; zebrafish

Mesh:

Year:  2014        PMID: 24612344      PMCID: PMC4028063          DOI: 10.1111/tra.12166

Source DB:  PubMed          Journal:  Traffic        ISSN: 1398-9219            Impact factor:   6.215


  37 in total

1.  Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling.

Authors:  Moumita Chaki; Rannar Airik; Amiya K Ghosh; Rachel H Giles; Rui Chen; Gisela G Slaats; Hui Wang; Toby W Hurd; Weibin Zhou; Andrew Cluckey; Heon Yung Gee; Gokul Ramaswami; Chen-Jei Hong; Bruce A Hamilton; Igor Cervenka; Ranjani Sri Ganji; Vitezslav Bryja; Heleen H Arts; Jeroen van Reeuwijk; Machteld M Oud; Stef J F Letteboer; Ronald Roepman; Hervé Husson; Oxana Ibraghimov-Beskrovnaya; Takayuki Yasunaga; Gerd Walz; Lorraine Eley; John A Sayer; Bernhard Schermer; Max C Liebau; Thomas Benzing; Stephanie Le Corre; Iain Drummond; Sabine Janssen; Susan J Allen; Sivakumar Natarajan; John F O'Toole; Massimo Attanasio; Sophie Saunier; Corinne Antignac; Robert K Koenekoop; Huanan Ren; Irma Lopez; Ahmet Nayir; Corinne Stoetzel; Helene Dollfus; Rustin Massoudi; Joseph G Gleeson; Sharon P Andreoli; Dan G Doherty; Anna Lindstrad; Christelle Golzio; Nicholas Katsanis; Lars Pape; Emad B Abboud; Ali A Al-Rajhi; Richard A Lewis; Heymut Omran; Eva Y-H P Lee; Shaohui Wang; Joann M Sekiguchi; Rudel Saunders; Colin A Johnson; Elizabeth Garner; Katja Vanselow; Jens S Andersen; Joseph Shlomai; Gudrun Nurnberg; Peter Nurnberg; Shawn Levy; Agata Smogorzewska; Edgar A Otto; Friedhelm Hildebrandt
Journal:  Cell       Date:  2012-08-03       Impact factor: 41.582

2.  The tubulin deglutamylase CCPP-1 regulates the function and stability of sensory cilia in C. elegans.

Authors:  Robert O'Hagan; Brian P Piasecki; Malan Silva; Prasad Phirke; Ken C Q Nguyen; David H Hall; Peter Swoboda; Maureen M Barr
Journal:  Curr Biol       Date:  2011-10-06       Impact factor: 10.834

3.  Regulated membrane protein entry into flagella is facilitated by cytoplasmic microtubules and does not require IFT.

Authors:  Olivier Belzile; Carmen I Hernandez-Lara; Qian Wang; William J Snell
Journal:  Curr Biol       Date:  2013-07-25       Impact factor: 10.834

4.  PDGFRα signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2-ERK1/2-p90RSK and AKT signaling pathways.

Authors:  Ditte L Clement; Sabine Mally; Christian Stock; Mette Lethan; Peter Satir; Albrecht Schwab; Stine F Pedersen; Søren T Christensen
Journal:  J Cell Sci       Date:  2012-12-21       Impact factor: 5.285

5.  Gene therapy rescues cilia defects and restores olfactory function in a mammalian ciliopathy model.

Authors:  Jeremy C McIntyre; Erica E Davis; Ariell Joiner; Corey L Williams; I-Chun Tsai; Paul M Jenkins; Dyke P McEwen; Lian Zhang; John Escobado; Sophie Thomas; Katarzyna Szymanska; Colin A Johnson; Philip L Beales; Eric D Green; James C Mullikin; Aniko Sabo; Donna M Muzny; Richard A Gibbs; Tania Attié-Bitach; Bradley K Yoder; Randall R Reed; Nicholas Katsanis; Jeffrey R Martens
Journal:  Nat Med       Date:  2012-09       Impact factor: 53.440

6.  Molecular basis of tubulin transport within the cilium by IFT74 and IFT81.

Authors:  Sagar Bhogaraju; Lukas Cajanek; Cécile Fort; Thierry Blisnick; Kristina Weber; Michael Taschner; Naoko Mizuno; Stefan Lamla; Philippe Bastin; Erich A Nigg; Esben Lorentzen
Journal:  Science       Date:  2013-08-30       Impact factor: 47.728

Review 7.  Current insights into renal ciliopathies: what can genetics teach us?

Authors:  Heleen H Arts; Nine V A M Knoers
Journal:  Pediatr Nephrol       Date:  2012-07-25       Impact factor: 3.714

8.  Bug22 influences cilium morphology and the post-translational modification of ciliary microtubules.

Authors:  Teresa Mendes Maia; Delphine Gogendeau; Carole Pennetier; Carsten Janke; Renata Basto
Journal:  Biol Open       Date:  2014-02-15       Impact factor: 2.422

9.  Direct recording and molecular identification of the calcium channel of primary cilia.

Authors:  Paul G DeCaen; Markus Delling; Thuy N Vien; David E Clapham
Journal:  Nature       Date:  2013-12-12       Impact factor: 49.962

10.  Primary cilia are specialized calcium signalling organelles.

Authors:  Markus Delling; Paul G DeCaen; Julia F Doerner; Sebastien Febvay; David E Clapham
Journal:  Nature       Date:  2013-12-12       Impact factor: 49.962

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